Pulmonary Function Changes and Diaphragmatic Paralysis Following Ultrasound Guided Supraclavicular Brachial Plexus Blockade: The Effects of Decreased Local Anesthetic Volume
This clinical trial is being conducted to study lung function and movement of the major muscle involved in breathing (the diaphragm) after a brachial plexus nerve block (nerve "freezing"). The purpose of this study is to find out what effects (good and bad) ultrasound guided nerve freezing has on the movement of the patient's diaphragm and their lung function.
The potential advantage of ultrasound guidance will be a lesser chance of freezing the nerves that innervate the diaphragm and thus having less of an effect on lung function.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Pulmonary Function Changes and Diaphragmatic Paralysis Following Ultrasound Guided Supraclavicular Brachial Plexus Blockade: The Effects of Decreased Local Anesthetic Volume|
- Forced expiratory volume in one second (FEV1) [ Time Frame: 60 minutes ] [ Designated as safety issue: No ]
- Forced vital capacity (FVC) [ Time Frame: 60 minutes ] [ Designated as safety issue: No ]
- Peak expiratory flow (PEF) [ Time Frame: 60 minutes ] [ Designated as safety issue: No ]
|Study Start Date:||October 2009|
|Estimated Study Completion Date:||April 2010|
|Estimated Primary Completion Date:||April 2010 (Final data collection date for primary outcome measure)|
Procedure: Supraclavicular Block
Baseline values of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and peak expiratory flow rates (PEFR) will be measured in both the sitting and supine position. Ultrasound-guided supraclavicular brachial plexus blocks will be performed in the supine position with a Pajunk 22g block needle and nerve stimulator. The patients will receive local anesthetic injection with 15 mL of 0.75% Bupivicaine. A maximum of 3 cc of 5% Dextrose will be utilized as contrast to confirm needle tip placement and fluid spread prior to injection of the local anesthetic.
At 60 minutes post-injection, FEV1, FVC, and PEFR measurements will be taken in the sitting and supine position.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01048021
|HSC Pain Management Centre|
|Winnipeg, Manitoba, Canada|
|Principal Investigator:||Patricia Mykytiuk, MD||Department of Anesthesia, University of Manitoba|