Working... Menu
Trial record 10 of 557 for:    Genetic AND family history

Family-based Genetic Long-term Study of Brain Function in Schizophrenia (FamilySchizo)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01045824
Recruitment Status : Unknown
Verified January 2010 by Taichung Veterans General Hospital.
Recruitment status was:  Recruiting
First Posted : January 11, 2010
Last Update Posted : January 15, 2010
Information provided by:
Taichung Veterans General Hospital

Brief Summary:
The goal of this research is to find out possible susceptible gene(s) in schizophrenic patients with family history and 5-year period functional changes of brain among the members of family, in order to further analysis factors and their interactions.

Condition or disease
Schizophrenia Blooddraw MRI

Detailed Description:
Schizophrenia is a serious mental disease, highly family inheritable inclination. By means of traditional psychiatry diagnosis, genetics and long term brain change researches will help to unveil the secret of schizophrenia and other factors. The advantage of comparative gene hybridization is that chromosome copy number alterations can be detected; this technique has been widely applied in many researches, such as cancer, mental retardation screening and autism. As we known, we are the first one use this technique in chromosome abnormality research for family history schizophrenic patient, this study also is the first one to track the relationship of long term brain function alteration and chromosome abnormality in Taiwan.

Layout table for study information
Study Type : Observational
Estimated Enrollment : 600 participants
Observational Model: Family-Based
Official Title: The Genetic Study of Longitudinal Brain Function Among Schizophrenic Patients With Family History
Study Start Date : January 2008
Estimated Primary Completion Date : January 2014
Estimated Study Completion Date : January 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Biospecimen Retention:   Samples With DNA
10-20cc of blood will be drawn for DNA analysis

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Schizophrenia family

Inclusion Criteria:

1.Psychiatry doctor diagnosed who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for schizophrenia or schizoaffective disorder, family history, age older than 15 will be recruited for participation in this study. Participants agree and sign informed consent forms will eligible to participate this experiment.

2.10-20c.c blood will be drawn from the participants. 3.Participants need to understand procedures and assays of this experiment. 4.At least one psychiatry doctor interview needed, participants and their family voluntarily join this interview, approximately 30-45min.

Exclusion Criteria:

  1. Participant can not understand procedures and assays of this experiment.
  2. Participant has another major mental disease other than the inclusion criteria.
  3. Participant has material abuse history, it could seriously influence diagnosis.
  4. Participant has combination diseases, it could seriously influence diagnosis.
  5. Psychopathy or psychosis can not be categorized in defined group.

Other considerations:

  1. Participants, age fewer than 20 needs to their deputy guardians (parents) and their own consent altogether.
  2. Participants who are inability needs to their deputy guardians (parents) and their own consent altogether.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01045824

Layout table for location contacts
Contact: Tsuo-Hung Lan, MD., PhD. 04-23592525 ext 3460
Contact: Chin Cheng, MD. 0966213994

Layout table for location information
Taichung Veterans General Hospital Recruiting
Taichung City, Taiwan, 40705
Contact: Tsuo-Hung Lan, MD., PhD.    886-4-23592525 ext 3460   
Contact: Chin Cheng, MD.    0966-213994   
Sub-Investigator: Chin Cheng, MD.         
Sponsors and Collaborators
Taichung Veterans General Hospital
Layout table for investigator information
Study Director: Tsuo-Hung Lan, MD., PhD. Taichung Veterans General Hospital
Study Director: Tsuo-Hung Lan, MD.,PhD Taichung Veterans General Hospital

Layout table for additonal information
Responsible Party: IRB TCVGH, Taichung Veterans General Hospital Identifier: NCT01045824     History of Changes
Other Study ID Numbers: C08202
First Posted: January 11, 2010    Key Record Dates
Last Update Posted: January 15, 2010
Last Verified: January 2010

Keywords provided by Taichung Veterans General Hospital:

Additional relevant MeSH terms:
Layout table for MeSH terms
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders