The Treatment of 2 Chinese Medicines in Clozapine-induced Hypersalivation in Schizophrenia
|ClinicalTrials.gov Identifier: NCT01045720|
Recruitment Status : Unknown
Verified January 2010 by Taichung Veterans General Hospital.
Recruitment status was: Recruiting
First Posted : January 11, 2010
Last Update Posted : January 14, 2010
|Condition or disease||Intervention/treatment||Phase|
|Schizophrenia Clozapine Hypersalivation Traditional Chinese Medicine||Drug: Suo Quan Wan, Wu Lin San Drug: Placebo||Phase 2|
Clozapine, an antipsychotic drug, is an important clinical medicine which is used for schizophrenia and preventing for its relapse; clozapine is better than some other atypical antipsychotics. However, in clinical uses, clozapine often could induce hypersalivation, it is not only influencing patient's appearance, also deteriorating sleeping quality which could deter patient discontinuing to take medicine.
In previous researches, Suo Quan Wan and Wu Lin San had been proven effective for hypersalivation and no significant side-effects, nevertheless, it still lack of systematical scientific trial reports. The ingredients of Suo Quan Wan are Wu Yao, San Yao and Yi Zhi Ren; the ingredients of Wu Lin San are Gui Zhi, Fu Ling, Zhu Ling, Ze Xie and Bai Ju, both have bi-directional regulatory functions for body fluid and saliva.
The goal of this research is hoping to combine traditional Chinese medicine medication and find out how to solve clozapine-induced hypersalivation, also reduce side-effect, medication compliance, improving life quality, improving social-function and reducing neopathy.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||45 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||The Treatment Effect of 2 Traditional Chinese Medicines[Suo Quan Wan]and [Wu Lin San] in Clozapine-induced Hypersalivation in Schizophrenia Patient.|
|Study Start Date :||January 2010|
|Estimated Primary Completion Date :||March 2010|
|Estimated Study Completion Date :||March 2010|
|Placebo Comparator: Placebo Comparator||
Drug: Suo Quan Wan, Wu Lin San
Suo Quan Wan Wu Lin San Placebo 2/daily
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01045720
|Contact: Tsuo-Hung Lan, MD., PhD.||04-23592525 ext firstname.lastname@example.org|
|Contact: Chia-Chun Hung, MD.||04-23592525 ext email@example.com|
|Taichung Veterans General Hospital||Recruiting|
|Taichung City, Taiwan, 40705|
|Contact: Tsuo-Hung Lan, MD., PhD. 886-4-23592525 ext 3460 firstname.lastname@example.org|
|Sub-Investigator: Chia-Chun Hung, MD.|
|Study Director:||Tsuo-Hung Lan, MD., PhD.||Taichung Veterans General Hospital|
|Study Director:||Tsuo-Hung Lan, MD.,PhD||Taichung Veterans General Hospital|