A Study of the Ability of Functional Magnetic Resonance Imaging (fMRI) to Detect and Characterize the Effects of Two Marketed Centrally Active Drugs, Placebo, and RO4917523 in Healthy Volunteers
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Randomized, Observer-blind, Placebo-controlled, Four-way Cross-over Study to Study the Ability of Functional Magnetic Resonance Imaging (fMRI) of the Brain to Detect and Characterize the Effects of Single Doses of a Selective Serotonin Reuptake Inhibitor (Escitalopram [Lexapro]), a Dopamine
Study Start Date
Primary Completion Date
Study Completion Date
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Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Adult patients, 18 to 45 years of age
In good general health
Weight of ≥120 lbs (55 kg) and a body mass index (BMI) between 18 to 30kg/m²
Males and females with reproductive potential: willing to use a reliable method of contraception
Evidence of clinically significant disease
Medical or surgical condition that could alter the absorption, metabolism, or elimination of drugs
Family history of sudden death or ventricular arrhythmia
History of any psychiatric disorder and/or marked anxiety
History of glaucoma
History (including family) of motor tic or diagnosis of Tourette's syndrome