Cognitive Function in Elderly Marathon Runners (APSOEM)
There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly. To the investigators knowledge no studies have evaluated the effects of extensive endurance exercise training on cognitive functions by studying elderly marathon runners and bicyclists. On the basis of the scientific literature published so far it is not known whether the beneficial impact of endurance exercise training depends on the intensity of training.
The investigators therefore designed a cohort study with adequate power in order to evaluate the effects of intensive endurance exercise training on cognition. This trial, an Austrian prospective cohort study in cognitive function of elderly marathon-runners (APSOEM) is being conducted and will compare neuropsychological performance outcomes of elderly marathon runners or bicyclists with controls matched concerning age, education years, occupation, and verbal intelligence.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Austrian Prospective Cohort Study in Cognitive Function of Elderly Marathon-runners|
- the Proportion of Subjects, Who Will Develop Mild Cognitive Impairment [ Time Frame: 10 years ] [ Designated as safety issue: No ]Hypothesis will be tested at the second follow-up examinations.
- Brain-derived Neurotrophic Factor (BDNF) [ Time Frame: Baseline and 5 years ] [ Designated as safety issue: No ]
- Self Rating by Questionnaires [ Time Frame: Baseline and 5 years ] [ Designated as safety issue: No ]The following self rating scales were used: WHO-5 Quality of Life Assessment (Braeher, E., Muehlan, H., Albani, C., & Schmidt, S. (2007). Testing and standardization of the German version of the EUROHIS-QOL and WHO-5 quality-of life-indices. Diagnostica, 53(2), 83-96.). Range: 0 - 25, higher scores indicate better quality of life.
- Insulin-like Growth Factor (IGF-1) [ Time Frame: Baseline and 5 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||December 2008|
|Estimated Study Completion Date:||December 2018|
|Primary Completion Date:||February 2014 (Final data collection date for primary outcome measure)|
Controls were subsequently contacted via personal contact and three additional advertisements (two in an Austrian newspaper ("Krone") and one in an Austrian bicyclist journal ("Bicyclist Sports"). The controls were matched according to age, sex and years of education
Runners participating in the 2008 Wachau half marathon (21,2 km) and the Vienna City marathon (42,5 km) as well as bicyclists participating at the Corinthian marathon (180km). Inclusion criteria:1) participation in at least one of these 3 marathons in the preceding two years,2)still in continuous training during the recruitment phase (at least 2 hours/week), 3) aged over 60. Exclusion criteria:(a) present or past exposure to neurotoxic substances (b) if they did not speak German as their native language (c) diseases that markedly affect CNS functions (d) manifest cardiovascular disease, (e) chronic alcoholism (daily alcohol intake > 60 g or diagnosed history of alcoholism) and (f) unwillingness to give informed consent.
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