Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma

This study has been completed.
Information provided by (Responsible Party):
Haukeland University Hospital Identifier:
First received: December 17, 2009
Last updated: July 3, 2014
Last verified: July 2014
The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.

Colloid Osmotic Pressure

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma, a Methodological Study

Further study details as provided by Haukeland University Hospital:

Primary Outcome Measures:
  • Colloid osmotic pressure [ Time Frame: 60 and 90 minuttes after implanting wicks ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA
Serum and interstitial fluid

Enrollment: 50
Study Start Date: December 2009
Study Completion Date: September 2010
Primary Completion Date: September 2010 (Final data collection date for primary outcome measure)
Detailed Description:
Fluid loss from circulating plasma volume is one of the contributors of oedema formation. Measurement of colloid osmotic pressure (COP) both in plasma and in interstitial fluid can be utilised in planing of fluid therapy in patients with oedema. Different methods of sampling interstitial fluid are well validated in animal models, but not in human. Sampling of interstitial fluid by subcutaneous sewn wicks is a well-known method and can be painful. Local anaesthetics can reduce pain. By comparing interstitial fluid taken from areas with or without application of local anaesthetics, a possible influence in COP values can be detected.

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers over 18 years.

Inclusion Criteria:

  • Adults over 18 years

Exclusion Criteria:

  • Ongoing illness
  • Medication
  Contacts and Locations
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Please refer to this study by its identifier: NCT01044979

Haukeland University Hospital
Bergen, Norway, 5021
Sponsors and Collaborators
Haukeland University Hospital
Principal Investigator: Hans Joergen T Guthe, MD Haukeland University Hospital
  More Information

No publications provided by Haukeland University Hospital

Additional publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Haukeland University Hospital Identifier: NCT01044979     History of Changes
Other Study ID Numbers: 071223
Study First Received: December 17, 2009
Last Updated: July 3, 2014
Health Authority: Norway:National Committee for Medical and Health Research Ethics

Keywords provided by Haukeland University Hospital:
Colloid osmotic pressure in interstitial fluid
Colloid osmotic pressure in plasma
Protein fractions in interstitial fluid processed this record on November 27, 2015