Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01044979
Recruitment Status : Completed
First Posted : January 8, 2010
Last Update Posted : July 4, 2014
Information provided by (Responsible Party):
Haukeland University Hospital

Brief Summary:
The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.

Condition or disease
Colloid Osmotic Pressure

Detailed Description:
Fluid loss from circulating plasma volume is one of the contributors of oedema formation. Measurement of colloid osmotic pressure (COP) both in plasma and in interstitial fluid can be utilised in planing of fluid therapy in patients with oedema. Different methods of sampling interstitial fluid are well validated in animal models, but not in human. Sampling of interstitial fluid by subcutaneous sewn wicks is a well-known method and can be painful. Local anaesthetics can reduce pain. By comparing interstitial fluid taken from areas with or without application of local anaesthetics, a possible influence in COP values can be detected.

Study Type : Observational
Actual Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma, a Methodological Study
Study Start Date : December 2009
Actual Primary Completion Date : September 2010
Actual Study Completion Date : September 2010

Primary Outcome Measures :
  1. Colloid osmotic pressure [ Time Frame: 60 and 90 minuttes after implanting wicks ]

Biospecimen Retention:   Samples Without DNA
Serum and interstitial fluid

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers over 18 years.

Inclusion Criteria:

  • Adults over 18 years

Exclusion Criteria:

  • Ongoing illness
  • Medication

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01044979

Haukeland University Hospital
Bergen, Norway, 5021
Sponsors and Collaborators
Haukeland University Hospital
Principal Investigator: Hans Joergen T Guthe, MD Haukeland University Hospital

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Haukeland University Hospital Identifier: NCT01044979     History of Changes
Other Study ID Numbers: 071223
First Posted: January 8, 2010    Key Record Dates
Last Update Posted: July 4, 2014
Last Verified: July 2014

Keywords provided by Haukeland University Hospital:
Colloid osmotic pressure in interstitial fluid
Colloid osmotic pressure in plasma
Protein fractions in interstitial fluid