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Measurement of Colloid Osmotic Pressure in Plasma and Interstitial Fluid in Children

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ClinicalTrials.gov Identifier: NCT01044641
Recruitment Status : Completed
First Posted : January 8, 2010
Last Update Posted : July 8, 2014
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study is to identify normal values of colloid osmotic pressure in interstitial fluid and plasma in healthy children between 2 and 10 years.

Condition or disease
Colloid Osmotic Pressure

Detailed Description:
Measurements of colloid osmotic pressure (COP) by sampling of interstitial fluid from subcutaneous tissue and plasma are well documented in animal models and human adult studies. COP plays a major role in transcapillary fluid balance and is valuable in fluid therapy planning in critically ill patients. There are no data regarding interstitial fluid COP values in neither sick nor healthy children. Sampling of interstitial fluid by the wick method in children who is under general anaesthesia (ear-nose-throat operations) gives the opportunity to identify normal COP values in this age group.

Study Design

Study Type : Observational
Actual Enrollment : 99 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Measurement of Colloid Osmotic Pressure in Plasma and Interstitial Fluid in Children
Study Start Date : December 2009
Primary Completion Date : May 2013
Study Completion Date : May 2013
Groups and Cohorts

Outcome Measures

Primary Outcome Measures :
  1. Colloid osmotic pressure [ Time Frame: 60 minuttes after wick insertion ]

Biospecimen Retention:   Samples Without DNA
Interstitial fluid and serum

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   2 Years to 10 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Secondary care clinic (ENT)

Inclusion Criteria:

  • Children from 2 to 10 years

Exclusion Criteria:

  • Medication
  • Ongoing illness
  • Syndromes
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01044641

Haukeland University Hospital
Bergen, Norway, 5021
Sponsors and Collaborators
Haukeland University Hospital
Principal Investigator: Hans Joergen T Guthe, MD Hanukeland University Hospital
More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Haukeland University Hospital
ClinicalTrials.gov Identifier: NCT01044641     History of Changes
Other Study ID Numbers: 065816
First Posted: January 8, 2010    Key Record Dates
Last Update Posted: July 8, 2014
Last Verified: July 2014

Keywords provided by Haukeland University Hospital:
Colloid Osmotic pressure in interstitial fluid
Colloid Osmotic pressure in plasma
Protein fractions in interstitial fluid