Evaluation of Insecticide Treated Nets and Wall Liners for the Prevention of Malaria (MTC-ITWL)
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|ClinicalTrials.gov Identifier: NCT01043796|
Recruitment Status : Completed
First Posted : January 7, 2010
Last Update Posted : February 3, 2015
|Condition or disease||Intervention/treatment||Phase|
|Malaria||Other: Insecticide treated nets and wall liners Other: Insecticide treated nets alone||Phase 3|
Insecticide treated nets (ITNs) have been shown to reduce malaria related morbidity and mortality and are increasingly being scaled up throughout sub-Saharan Africa. However, ITNs alone are unlikely to reduce transmission to zero in most settings and additional vector control tools are necessary. One new promising strategy is the use of insecticide treated wall liners (ITWLs). These are textiles treated with an insecticide that are used to line the inner walls of houses. The wall liners are considered a long-lasting alternative to indoor residual spraying which is also used for malaria vector control but is expensive to implement.
Within 6 pairs of villages, we plan to randomly allocate one village in each pair to receive either ITNs or ITNs plus ITWLs. Households will be randomly selected from each village and all children between the ages of 6 months and 11 years will be enrolled in a cohort study. The children will be cleared of existing infections and then followed monthly until they are found to be infected with malaria. The study will last for 6 months and will demonstrate whether the ITWLs provide additional protection against malaria over that provided by the use of ITNs.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||1730 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Malaria Transmission Consortium: The Added Effects of Insecticide Treated Materials, Artemisinin-containing Combination Treatments, and Larviciding on Malaria Transmission and Illness|
|Study Start Date :||May 2010|
|Actual Primary Completion Date :||June 2011|
|Actual Study Completion Date :||December 2014|
|Experimental: Insecticide treated nets and wall liners||
Other: Insecticide treated nets and wall liners
Participants will be provided a long-lasting insecticide treated net recommended by the WHO Pesticide Evaluation Scheme. Households where participants reside will be fitted with insecticide treated wall liners.
|Active Comparator: Insecticide treated nets alone||
Other: Insecticide treated nets alone
Participants will be provided with a long-lasting insecticide treated net recommended by the WHO Pesticide Evaluation Scheme
- Incidence of new malaria infections [ Time Frame: Monthly ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01043796
|Kenya Medical Research Institute|
|Kisumu, Nyanza, Kenya|
|Principal Investigator:||John E Gimnig, Ph.D.||Centers for Disease Control and Prevention|