-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.
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ClinicalTrials.gov Identifier: NCT01043445 |
Recruitment Status
:
Completed
First Posted
: January 6, 2010
Last Update Posted
: October 9, 2014
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Type 2 Diabetes | Dietary Supplement: GPR 119 agonist, 2-oleyl glycerol Dietary Supplement: Oleic acid Dietary Supplement: Vehicle | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 8 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Single (Participant) |
Primary Purpose: | Basic Science |
Official Title: | G Protein-coupled Receptor in the Intestine (GPR 119) Stimulated GLP-1 Secretion |
Study Start Date : | September 2009 |
Actual Primary Completion Date : | March 2010 |
Actual Study Completion Date : | April 2010 |

Arm | Intervention/treatment |
---|---|
Experimental: GPR119 agonist, 2-oleoyl glycerol
2-oleoyl glycerol; 2g. and vehicle
|
Dietary Supplement: GPR 119 agonist, 2-oleyl glycerol
Emulgation, 50 ml. containing 2g 2OG
Dietary Supplement: Vehicle
Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol
|
Active Comparator: Oleic acid
oleic acid; 3.2g and vehicle
|
Dietary Supplement: Oleic acid
Emulgation, 50 ml. containing 1.54g of oleic acid
Dietary Supplement: Vehicle
Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol
|
Placebo Comparator: Vehicle
5 ml. of glycerol and 5 ml 96% ethanol
|
Dietary Supplement: Vehicle
Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol
|
- The effect of this newly discovered GPR 119 agonist on gut hormone responses, in particular GLP-1 in response of the different meals administered to the subjects [ Time Frame: 1 year ]
- Glucose homeostasis, gall bladder contraction in response of the different meals administered to the subjects [ Time Frame: 1 year ]

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Ages Eligible for Study: | 18 Years to 30 Years (Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Healthy caucasians v- Normal OGTT (75 g of glucose) according to WHO's criteria
- Normal hemoglobin
- Informed consent
Exclusion Criteria:
- Liver disease (ALAT> 2x normal level)
- Nephropathy (s-creatinin >130 microM or albuminuria)
- Relatives with type 2 diabetes

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01043445
Denmark | |
Department of Clinical Physiology, Glostrup Hospital | |
Glostrup, Denmark, 2600 |
Principal Investigator: | Katrine B Hansen, MD | Glostrup Hospital, University of Copenhagen | |
Study Director: | Filip K Knop, MD, Ph.d | Gentofte Hospital | |
Study Director: | Harald S Hansen, professor | Farmaceutical Faculty, University of Copenhagen | |
Study Director: | Jens J Holst, MD;DMSc | Biomedical Science, University of Copenhagen |
Responsible Party: | Katrine Bagge Hansen, MD, Ph.d, Glostrup University Hospital, Copenhagen |
ClinicalTrials.gov Identifier: | NCT01043445 History of Changes |
Other Study ID Numbers: |
GPR119 |
First Posted: | January 6, 2010 Key Record Dates |
Last Update Posted: | October 9, 2014 |
Last Verified: | October 2014 |
Keywords provided by Katrine Bagge Hansen, Glostrup University Hospital, Copenhagen:
GPR 119 GLP-1 secretion 2-oleoyl-glycerol Dietary supplementation |
Additional relevant MeSH terms:
Glycerol Cryoprotective Agents Protective Agents Physiological Effects of Drugs |