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Multicenter Cross Sectional Study of Primary Intestine Lymphoma

This study has been completed.
Information provided by:
Samsung Medical Center Identifier:
First received: January 4, 2010
Last updated: July 27, 2010
Last verified: July 2010
The purpose of this study is to determine whether whether surgical resection followed by chemotherapy is superior to systemic chemotherapy alone in terms of treatment outcome and quality of life (QOL) in patients with primary intestinal lymphoma.

Non-Hodgkin Lymphoma of Intestine

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Multicenter Cross Sectional Study of Primary Intestine Lymphoma: Treatment Outcome and Quality of Life

Resource links provided by NLM:

Further study details as provided by Samsung Medical Center:

Primary Outcome Measures:
  • Overall survival [ Time Frame: Study entry ]

Secondary Outcome Measures:
  • Quality of life [ Time Frame: Study entry ]

Enrollment: 545
Study Start Date: September 2008
Study Completion Date: March 2010
Primary Completion Date: March 2010 (Final data collection date for primary outcome measure)
Primary mass was resected and systemic chemotherapy was performed as an adjuvant treatment
Only treated with chemotherapy

Detailed Description:
Intestine is the one of commonly involved extranodal sites of non-Hodgkin's lymphoma (NHL). Thus, small and large Intestine account for approximately 30-40% of primary gastrointestinal tract lymphoma. More than 70% of intestinal lymphoma presents as localized disease, and surgery such as bowel resection is performed in many patients with intestinal lymphoma for diagnosis and treatment. However, it is still unclear whether surgical resection followed by chemotherapy is superior to systemic chemotherapy alone in terms of treatment outcome and quality of life (QOL). Thus, we analyze the clinical features and treatment outcome of patients with NHL of intestine, and at the same time perform a multicenter cross-sectional study about the QOL in survivors of intestine NHL. We evaluates the treatment outcomes of patients with intestine NHL from hospitals affiliated with the Consortium for Improving Survival of Lymphoma (CISL) in Korea. We assess the QOL of survivors who completed their treatment using the EORTC QLQ-C30 questionnaire.

Ages Eligible for Study:   15 Years to 85 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
University hosptial, general hospital, Cancer institute

Inclusion Criteria:

  • Primary intestine lymphoma.

Definition of primary intestine lymphoma:

  1. Dominant site should be small and large intestine with or without regional lymph node involvement
  2. Distant lymph node involvement can be allowed if the intestine lesion is the presenting site
  3. Contiguous involvement of other organs such as liver, spleen can be allowed

Exclusion Criteria:

  • Intestine involvement as a dissemination process in stage IV nodal lymphoma
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Please refer to this study by its identifier: NCT01043302

Korea, Republic of
Samsung Medical Center
Seoul, Korea, Republic of, 135-710
Sponsors and Collaborators
Samsung Medical Center
Principal Investigator: Seok Jin Kim, MD.,PhD Samsung Medical Center
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Kim, Seok Jin, Samsung Medical Center Identifier: NCT01043302     History of Changes
Other Study ID Numbers: 2008-09-060
Study First Received: January 4, 2010
Last Updated: July 27, 2010

Keywords provided by Samsung Medical Center:
lymphoma, intestine, outcome, quality of life

Additional relevant MeSH terms:
Lymphoma, Non-Hodgkin
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases processed this record on May 22, 2017