Evaluation of Image Quality Over Time After Injection of the ﬂuorescein Sodium for Confocal Laser Endomicroscopy
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Confocal laser endomicroscopy (CLE) is a newly developed endoscopic technique. The most commonly used fluorescent substance is Fluorescein sodium.The plasma half-life of ﬂuorescein is 11 minutes. A recent test estimated that ﬂuorescein-based CLSM(confocal laser scanning microscopy) of the upper-GI tract of pigs delivers the best contrast and image quality within the ﬁrst 8 minutes after injection of ﬂuorescein .However, despite its increasing use in clinical examination,there are no data on contrast dynamics and image quality over time after injection of the ﬂuorescein sodium in the inspection of gastrointestinal tract of human being.
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Ages Eligible for Study:
18 Years to 60 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
patients without any disease of heart,liver or kidney;patients without serious gastritis and other serious stomach lesions.
These subjects will include male or female aged between 18 and 60 years with indications for upper-endoscopy ,but without serious gastritis and other serious stomach lesions
Complications such as gastric and/or duodenal peptic ulcer, stenosis
Esophageal, gastric or duodenal cancer or other malignancy
History of stomach surgery
A history of bronchial asthma, or known allergy to fluorescein.
Pregnant or breast‐feeding (for females)
Below 18 or above 60 years of age
Severe comorbidities ( e.g. such as renal failure, congestive cardiac failure, liver cirrhosis).