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ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01041339
First Posted: December 31, 2009
Last Update Posted: December 15, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Alexhander Izhaki, Wolfson Medical Center
  Purpose
A blood test (2-3 cc peripheral venous blood) drawn /used from already available required lab tests to distinguish between pericarditis accompanied with electrocardiogram (ECG) signs mimicking infarction. A test of clinical potential if proven to be able to support either origin of acute chest pain etiology.

Condition
Acute Chest Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: ST Elevation (Acute Coronary Syndrome Versus Pericarditis;Could Measurement of Lp-associated PLA2 -a Vascular Specific Marker of Inflammation- be Helpful to the Clinician?

Resource links provided by NLM:


Further study details as provided by Alexhander Izhaki, Wolfson Medical Center:

Biospecimen Retention:   Samples Without DNA
plasma kept in -80 celsius refrigerator

Enrollment: 40
Study Start Date: January 2010
Study Completion Date: January 2012
Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
acute chest pain ST elevation
patients admitted with acute chest pain sharing ST elevation in ER-ECG and elevated troponin
controls
asymptomatic patients

Detailed Description:

Too many times young patients presenting with acute chest pain are referred to invasive angiography or treated with anticoagulation therapy a measure of detrimental effect in those inflicted with acute pericarditis.

A simple blood test (the PLAC test) may have some value in aiding rapid diagnosis saving need for cath.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
acute chest pain patients admitted to ICCU with acute ST elevation and elevated troponin
Criteria

Inclusion Criteria:

  • acute chest pain
  • acute ST elevation
  • elevated troponin I

Exclusion Criteria:

  • patients with recent (> 24 hour chest pain) myocardial infarction
  • refusing to provide blood samples
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01041339


Locations
Israel
The E.Wolfson MC
Holon, Israel, 52100
Sponsors and Collaborators
Alexhander Izhaki
Investigators
Principal Investigator: Alexander J Izhaki, MD The E.Wolfson MC
  More Information

Additional Information:
Responsible Party: Alexhander Izhaki, MD, Wolfson Medical Center
ClinicalTrials.gov Identifier: NCT01041339     History of Changes
Other Study ID Numbers: 0075-09-WOMC
First Submitted: December 30, 2009
First Posted: December 31, 2009
Last Update Posted: December 15, 2015
Last Verified: June 2011

Keywords provided by Alexhander Izhaki, Wolfson Medical Center:
LpPLA2
ST elevation
acute pericarditis

Additional relevant MeSH terms:
Syndrome
Acute Chest Syndrome
Pericarditis
Disease
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Anemia
Hematologic Diseases
Hemoglobinopathies
Genetic Diseases, Inborn
Heart Diseases
Cardiovascular Diseases