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ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?

This study has been completed.
Information provided by (Responsible Party):
Alexhander Izhaki, Wolfson Medical Center Identifier:
First received: December 30, 2009
Last updated: December 13, 2015
Last verified: June 2011
A blood test (2-3 cc peripheral venous blood) drawn /used from already available required lab tests to distinguish between pericarditis accompanied with electrocardiogram (ECG) signs mimicking infarction. A test of clinical potential if proven to be able to support either origin of acute chest pain etiology.

Acute Chest Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: ST Elevation (Acute Coronary Syndrome Versus Pericarditis;Could Measurement of Lp-associated PLA2 -a Vascular Specific Marker of Inflammation- be Helpful to the Clinician?

Resource links provided by NLM:

Further study details as provided by Wolfson Medical Center:

Biospecimen Retention:   Samples Without DNA
plasma kept in -80 celsius refrigerator

Enrollment: 40
Study Start Date: January 2010
Study Completion Date: January 2012
Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
acute chest pain ST elevation
patients admitted with acute chest pain sharing ST elevation in ER-ECG and elevated troponin
asymptomatic patients

Detailed Description:

Too many times young patients presenting with acute chest pain are referred to invasive angiography or treated with anticoagulation therapy a measure of detrimental effect in those inflicted with acute pericarditis.

A simple blood test (the PLAC test) may have some value in aiding rapid diagnosis saving need for cath.


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
acute chest pain patients admitted to ICCU with acute ST elevation and elevated troponin

Inclusion Criteria:

  • acute chest pain
  • acute ST elevation
  • elevated troponin I

Exclusion Criteria:

  • patients with recent (> 24 hour chest pain) myocardial infarction
  • refusing to provide blood samples
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Please refer to this study by its identifier: NCT01041339

The E.Wolfson MC
Holon, Israel, 52100
Sponsors and Collaborators
Alexhander Izhaki
Principal Investigator: Alexander J Izhaki, MD The E.Wolfson MC
  More Information

Additional Information:
Responsible Party: Alexhander Izhaki, MD, Wolfson Medical Center Identifier: NCT01041339     History of Changes
Other Study ID Numbers: 0075-09-WOMC
Study First Received: December 30, 2009
Last Updated: December 13, 2015

Keywords provided by Wolfson Medical Center:
ST elevation
acute pericarditis

Additional relevant MeSH terms:
Acute Chest Syndrome
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Hematologic Diseases
Genetic Diseases, Inborn
Heart Diseases
Cardiovascular Diseases processed this record on April 24, 2017