ClinicalTrials.gov
ClinicalTrials.gov Menu

Polymorphism of Estrogen Genes in Stroke

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01040182
Recruitment Status : Unknown
Verified December 2010 by Taipei Medical University WanFang Hospital.
Recruitment status was:  Recruiting
First Posted : December 29, 2009
Last Update Posted : December 3, 2010
Sponsor:
Information provided by:
Taipei Medical University WanFang Hospital

Brief Summary:
The purpose of this study is to explore the association between the genetic polymorphisms of estrogen-related genes, including estrogen synthesis, metabolizing, and receptor genes, and ischemic stroke. Furthermore, independent and joint effects of traditional risk factors and estrogen related genes on risk of stroke in young adults will also be examined in this study.

Condition or disease
Ischemic Stroke

Detailed Description:
Cerebrovascular diseases are the third leading cause of death in Taiwan in 2007. It is also the most important reason for disability among elderly adults. Sex hormones are well reported to be associated with cardiovascular disease risk. Several studies showed that estrogens have been shown to have beneficial effects on the cardiovascular system via favorable effects on anti-inflammatory effects. Genetic polymorphisms of estrogen related genes are speculated to influence estrogen level and will count for human susceptible to risk of stroke in young adults. In addition, several studies showed that the decrease in estrogen-induced vascular inflammatory markers including adhesion molecules and chemokines might be the mechanism for vascular protection. Recently, a novel and unique mechanisms for 17β-Estradiol (E2) anti-inflammatory activity which is E2 prevents inflammatory gene transcription induced by inflammatory agents by inhibiting NF-κB intracellular transport was found. Therefore, we proposed a study to explore the association between the genetic polymorphisms of estrogen-related genes, including estrogen synthesis, metabolizing, receptor genes, and NF-κB and ischemic stroke in young adults.

Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Polymorphism of Estrogen Genes in Stroke
Study Start Date : December 2009
Estimated Primary Completion Date : November 2010
Estimated Study Completion Date : November 2010

Resource links provided by the National Library of Medicine

Drug Information available for: Estrogens
U.S. FDA Resources

Group/Cohort
ischemic stroke patients
healthy subjects without cerebrovascular disease



Biospecimen Retention:   Samples With DNA
Buffy coat and plasma will be retained.


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
A total of 300 incident ischemic stroke patients will be recruited in the program project.
Criteria

Inclusion Criteria:

  • incident ischemic stroke patients diagnosed by CT or MRI.

Exclusion Criteria:

  • non ischemic stroke patients

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01040182


Locations
Taiwan
WanFang Hospital Recruiting
Taipei, Taiwan
Contact: Hung-Yi Chiou, Ph.D.    886-2-27361661 ext 6512    hychiou@tmu.edu.tw   
Sub-Investigator: Chin-I Chen, M.D.         
Sponsors and Collaborators
Taipei Medical University WanFang Hospital
Investigators
Principal Investigator: Hung-Yi Chiou Taipei Medical University WanFang Hospital

Responsible Party: Hung-Yi Chiou, Ph.D./PI, National Science Council
ClinicalTrials.gov Identifier: NCT01040182     History of Changes
Other Study ID Numbers: NSC 97-2321-B-038-002
First Posted: December 29, 2009    Key Record Dates
Last Update Posted: December 3, 2010
Last Verified: December 2010

Keywords provided by Taipei Medical University WanFang Hospital:
ischemic stroke patients

Additional relevant MeSH terms:
Stroke
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Estrogens
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs