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Genetic Basis of Odor Discrimination

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ClinicalTrials.gov Identifier: NCT01039935
Recruitment Status : Completed
First Posted : December 25, 2009
Last Update Posted : September 6, 2012
Sponsor:
Information provided by (Responsible Party):
Rockefeller University

Brief Summary:
Prior to the main study we will perform a pilot study on 60 subjects. The purpose of the pilot study is to identify the range of odor concentrations that will be used in the main study and to optimize the tasks performed in the main study.

Condition or disease
Non-smokers

Study Type : Observational
Actual Enrollment : 512 participants
Time Perspective: Prospective
Official Title: Genetic Basis of Odor Discrimination
Study Start Date : November 2009
Actual Primary Completion Date : August 2012
Actual Study Completion Date : August 2012



Primary Outcome Measures :
  1. Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors [ Time Frame: 3 years ]

Secondary Outcome Measures :
  1. concentration at which odors need to be added to allow for discrimination; thresholds to all six odors; verbal descriptors assigned to all six odors [ Time Frame: 3 years ]

Biospecimen Retention:   Samples With DNA
Blood sample taken


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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy volunteers
Criteria

Inclusion Criteria:

  1. Age 18-50
  2. Current non-smokers

Exclusion Criteria:

  1. Current smokers
  2. Allergy to fragrances or smells of any kind
  3. Active head cold, upper respiratory infection, or seasonal nasal allergies
  4. History of nasal health problems, including endoscopic nasal surgery for sinus conditions or polyp removal.
  5. Pre-existing medical condition that has caused anosmia or near total loss of the sense of smell, such as: head injury, cancer therapy, radiation to head and neck, or alcoholism

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01039935


Locations
United States, New York
The Rockefeller University
New York, New York, United States, 10065
Sponsors and Collaborators
Rockefeller University
Investigators
Principal Investigator: Leslie Vosshall, PhD The Rockefeller University

Responsible Party: Rockefeller University
ClinicalTrials.gov Identifier: NCT01039935     History of Changes
Other Study ID Numbers: LVO-0684
First Posted: December 25, 2009    Key Record Dates
Last Update Posted: September 6, 2012
Last Verified: September 2012

Keywords provided by Rockefeller University:
Odor Discrimination