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Genetic Basis of Odor Discrimination

This study has been completed.
Information provided by (Responsible Party):
Rockefeller University Identifier:
First received: December 23, 2009
Last updated: September 5, 2012
Last verified: September 2012
Prior to the main study we will perform a pilot study on 60 subjects. The purpose of the pilot study is to identify the range of odor concentrations that will be used in the main study and to optimize the tasks performed in the main study.


Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Genetic Basis of Odor Discrimination

Further study details as provided by Rockefeller University:

Primary Outcome Measures:
  • Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors [ Time Frame: 3 years ]

Secondary Outcome Measures:
  • concentration at which odors need to be added to allow for discrimination; thresholds to all six odors; verbal descriptors assigned to all six odors [ Time Frame: 3 years ]

Biospecimen Retention:   Samples With DNA
Blood sample taken

Enrollment: 512
Study Start Date: November 2009
Study Completion Date: August 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy volunteers

Inclusion Criteria:

  1. Age 18-50
  2. Current non-smokers

Exclusion Criteria:

  1. Current smokers
  2. Allergy to fragrances or smells of any kind
  3. Active head cold, upper respiratory infection, or seasonal nasal allergies
  4. History of nasal health problems, including endoscopic nasal surgery for sinus conditions or polyp removal.
  5. Pre-existing medical condition that has caused anosmia or near total loss of the sense of smell, such as: head injury, cancer therapy, radiation to head and neck, or alcoholism
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01039935

United States, New York
The Rockefeller University
New York, New York, United States, 10065
Sponsors and Collaborators
Rockefeller University
Principal Investigator: Leslie Vosshall, PhD The Rockefeller University
  More Information

Responsible Party: Rockefeller University Identifier: NCT01039935     History of Changes
Other Study ID Numbers: LVO-0684
Study First Received: December 23, 2009
Last Updated: September 5, 2012

Keywords provided by Rockefeller University:
Odor Discrimination processed this record on August 16, 2017