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Attempts to Stop/Reduce Marijuana Among Dependent Users

This study has been completed.
National Institute on Drug Abuse (NIDA)
Information provided by (Responsible Party):
John Hughes, University of Vermont Identifier:
First received: December 24, 2009
Last updated: October 27, 2016
Last verified: October 2016
The purpose of the study is to determine why and how marijuana users stop or reduce their marijuana use.

Marijuana Abuse Marijuana Dependence

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Attempts to Stop/Reduce Marijuana Among Dependent Users

Resource links provided by NLM:

Further study details as provided by John Hughes, University of Vermont:

Primary Outcome Measures:
  • initiation of a quit or reduction attempt [ Time Frame: during 3 months of monitoring ]

Secondary Outcome Measures:
  • duration of a quit attempt [ Time Frame: during the 3 months of monitoring ]

Enrollment: 234
Study Start Date: June 2010
Study Completion Date: October 2012
Primary Completion Date: October 2012 (Final data collection date for primary outcome measure)
Detailed Description:
The major aim of this study is to provide a better understanding of attempts to stop or reduce marijuana use that can be used to develop better behavioral treatments for marijuana dependence. The application will focus on adult daily marijuana users who try to stop or reduce their marijuana use in a real-world setting. Although prospective, natural history studies describing attempts to stop or reduce alcohol, heroin and tobacco use have proved useful, we know of no such study among adult marijuana users. Two pilot studies will develop measures and assess compliance with our procedures. The main study will recruit up to 400 adult marijuana smokers with the goal of a sample size of 200 participants with adequate compliance. Participants will call an Interactive Voice Recording (IVR) system daily for 3 months to report marijuana use, quit/reduction attempts, and events that might increase or decrease the probability of initiating a quit/reduction attempt or the success of an attempt. Follow-up at 6 months will track recent marijuana and other drug use. Knowing what motivates marijuana users to try to stop or reduce, and knowing which strategies for stopping marijuana use are successful, can help develop treatments for marijuana dependence. For example, if stopping tobacco when trying to stop marijuana decreases the chance of stopping marijuana, then smoking cessation should be done after stopping marijuana. Or if reducing marijuana often leads to cessation, then convincing those not interested in quitting marijuana to first try reducing may be helpful.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
adults 18 and older

Inclusion Criteria:

  • daily marijuana smokers for at least 1 year

Exclusion Criteria:

  • pregnant women
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01039415

United States, Vermont
University of Vermont
Burlington, Vermont, United States, 05401
Sponsors and Collaborators
University of Vermont
National Institute on Drug Abuse (NIDA)
Principal Investigator: John Hughes, MD University of Vermont
  More Information

Responsible Party: John Hughes, Professor of psychiatry, University of Vermont Identifier: NCT01039415     History of Changes
Other Study ID Numbers: CHRBS #09-005
R01DA024691 ( U.S. NIH Grant/Contract )
Study First Received: December 24, 2009
Last Updated: October 27, 2016

Keywords provided by John Hughes, University of Vermont:
marijuana abuse
marijuana dependence
substance-related disorder

Additional relevant MeSH terms:
Marijuana Abuse
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders processed this record on September 20, 2017