Optical Coherence Tomography: An Adjunct to Flexible Bronchoscopy in the Diagnosis of Lung Cancer (OCT)
Optical coherence tomography will be a feasible adjunct to flexible bronchoscopy, and provide images with good sensitivity and specificity to determine the presence of endobronchial malignancies.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Optical Coherence Tomography: An Adjunct to Flexible Bronchoscopy in the Diagnosis of Lung Cancer|
- OCT image sensitivity and specificity in diagnosis of lung cancer. [ Time Frame: Every 3 months ] [ Designated as safety issue: No ]
- Feasibility and safety of obtaining OCT images during flexible bronchoscopy. [ Time Frame: Every 3 months ] [ Designated as safety issue: Yes ]
|Study Start Date:||February 2009|
|Study Completion Date:||September 2012|
|Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
Optical Coherence Tomography
Examine OCT images and compare them to conventional biopsies in same subject.
Device: Optical Coherence Tomography
Obtain OCT images.
Other Name: Imalux Niris
OCT could become a powerful tool in diagnostic pulmonary medicine, not only in the early recognition of lung cancer, but also in the evaluation and monitoring of microstructures in the lower respiratory tract that are affected by other inflammatory or invasive disease processes. Initially, OCT could be used to guide the location of biopsies which would likely provide increased specificity to traditional bronchoscopy. However, if the sensitivity and specificity of OCT images are comparable to histologic specimens, this technology may in the future provide a non-invasive "optical biopsy", which could potentially obviate the need for conventional biopsies in patients with high risks for complications, such as bleeding.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01039311
|United States, Oklahoma|
|OU Health Sciences Center|
|Oklahoma City, Oklahoma, United States, 73104|
|Principal Investigator:||Jean Keddissi, MD||University of Oklahoma|