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Trial record 20 of 370 for:    "Mouth Neoplasms"

Epstein-Barr Detection in Oral Cancer

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ClinicalTrials.gov Identifier: NCT01039272
Recruitment Status : Completed
First Posted : December 24, 2009
Last Update Posted : June 25, 2015
Sponsor:
Information provided by (Responsible Party):
UPECLIN HC FM Botucatu Unesp

Brief Summary:
The aim of this study is to analyze oral squamous cell carcinoma and healthy oral mucosa for the possible presence of Epstein-Barr virus (EBV).

Condition or disease
Oral Cancer

Detailed Description:
Epstein-Barr virus has been implicated in a range of malignant neoplasms, including in some studies, in the aetiology of oral squamous cell carcinoma but the influence of EBV in oral cancer remains unclear. This study will examine the prevalence of EBV infection in oral cancer by means of nested polymerase chain reaction.

Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Epstein-Barr Detection in Squamous Cell Carcinoma and Healthy Oral Mucosa
Study Start Date : March 2008
Actual Primary Completion Date : April 2008
Actual Study Completion Date : June 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Oral Cancer

Group/Cohort
oral cancer
patients with oral squamous cell carcinoma
control group
healthy patients without any oral pathology



Primary Outcome Measures :
  1. presence of EBV [ Time Frame: 1 hour ]
    Epstein-Barr virus has been implicated in a range of malignant neoplasms, including in some studies, in the aetiology of oral squamous cell carcinoma but the influence of EBV in oral cancer remains unclear. This study will examine the prevalence of EBV infection in oral cancer by means of nested polymerase chain reaction.


Biospecimen Retention:   Samples With DNA
paraffin-embedded tissue samples


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Ages Eligible for Study:   40 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
oral care clinic, community sample
Criteria

Inclusion Criteria:

  • patients of Oral Cancer Centre - UNESP/Araçatuba - SP
  • with oral squamous cell carcinoma

Exclusion Criteria:

  • without oral squamous cell carcinoma

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01039272


Locations
Brazil
Department of Pathology and Propaedeutics, Sao Paulo State University, Unesp, Araçatuba/SP
Araçatuba, São Paulo, Brazil, 16025-050
Sponsors and Collaborators
UPECLIN HC FM Botucatu Unesp
Investigators
Principal Investigator: Glauco Issamu I Miyahara, Professor Department of Pathology and Propaedeutics, Sao Paulo State University, Unesp, Araçatuba/SP
Study Chair: Lívia T Arêde, student Department of Pathology and Propaedeutics, Sao Paulo State University, Unesp, Araçatuba/SP

Additional Information:
Responsible Party: UPECLIN HC FM Botucatu Unesp
ClinicalTrials.gov Identifier: NCT01039272     History of Changes
Other Study ID Numbers: upeclin/FOA-Unesp-03
First Posted: December 24, 2009    Key Record Dates
Last Update Posted: June 25, 2015
Last Verified: June 2015

Keywords provided by UPECLIN HC FM Botucatu Unesp:
oral cancer
EBV
PCR

Additional relevant MeSH terms:
Mouth Neoplasms
Lip Neoplasms
Head and Neck Neoplasms
Neoplasms by Site
Neoplasms
Mouth Diseases
Stomatognathic Diseases
Lip Diseases