Circulating Endothelial Compartment During Normal and Pathological Aging (VIMOPEIL)
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ClinicalTrials.gov Identifier: NCT01038700
: December 24, 2009
Last Update Posted
: October 1, 2015
Assistance Publique - Hôpitaux de Paris
Fondation pour la Recherche Médicale
Assistance Publique Hopitaux De Marseille
Institut National de la Santé Et de la Recherche Médicale, France
This part of the project aims to describe changes in markers of vascular competence (Endothelial Microparticles Platelet (EMP), Circulating endothelial cells (CEC) and Circulating endothelial progenitors (EPC)) at different ages of lifespan both in physiological state and in response to hypoxia-induced vascular stress.
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Ages Eligible for Study:
10 Years to 90 Years (Child, Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Healthy volunteers of 20-30 and 60-70 years old
Non smokers male
Biological test in normal values : lipids, glucose, TGO, TGT, alkaline phosphatases, gamma-GT, bilirubin, creatinine, ionogram, Ca++, albumin, proteins, WBC, platelets count, coagulation tests (APTT, PT, Fibrinogen).
Negative HIV1 and 2, HBV (Hbs antigen) and HCV serology.
Normal ECG 12 derivations, arterial pressure and cardiac frequency.
Evaluative disease in the past 10 days
Treatments with antiplatelets agents, oral or injectable anticoagulant
Statins, glitazones, EPO, G-CSF
Blood donation in the 3 months preceding the study
People in period of exclusion on the National File of the people who lend themselves to biomedical research
Refusal or linguistic or psychic incapacity to sign the enlightened consent
Biological parameters apart from the usual values of the healthy subject (Hb<10 g/dL, TGO/TGT > 2 times higher limit of normal values)
Prone not being able to subject to the constraints protocol (for example, not cooperating, incompetent to go to the visits of follow-up and probably incompetent to finish the study).