Cognitive Dysfunction After Aneurysmal Subarachnoid Haemorrhage

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2015 by Chinese University of Hong Kong
Information provided by (Responsible Party):
George KC Wong, Chinese University of Hong Kong Identifier:
First received: December 22, 2009
Last updated: February 2, 2015
Last verified: February 2015

This is a longitudinal, multi-center, prospective study of aneurysmal subarachnoid haemorrhage patients in neurosurgical units in Hong Kong.

Condition Intervention
Cognitive Dysfunction
Other: Cognitive assessment

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Cognitive Dysfunction After Aneurysmal Subarachnoid Haemorrhage

Resource links provided by NLM:

Further study details as provided by Chinese University of Hong Kong:

Primary Outcome Measures:
  • Cognitive dysfunction [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Modified Rankin Scale [ Time Frame: 12 months ] [ Designated as safety issue: No ]
  • ShortForm36(SF-36) [ Time Frame: 12 months ] [ Designated as safety issue: No ]
  • Lawton-Instrumental-ActivityOfDailyLiving(IADL) [ Time Frame: 12 months ] [ Designated as safety issue: No ]
  • Stroke-specific-QOL [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 240
Study Start Date: March 2009
Estimated Study Completion Date: March 2018
Estimated Primary Completion Date: March 2017 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
aSAH patients
Cognitive assessment
Other: Cognitive assessment
Cognitive and functional assessments at 2-4 weeks, 3 months and 12 months.
Other Name: Cognition

Detailed Description:

The investigators aim to recruit a total of 240 aneurysmal subarachnoid haemorrhage patients. The schedule for neuropsychological and functional assessments will be phased in at the second to third week, the third month, and the twelve months after the initial haemorrhage.


Ages Eligible for Study:   21 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Aneurysmal subarachnoid hemorrhage patients


Inclusion criteria

  1. Spontaneous subarachnoid haemorrhage with intracranial aneurysms as aetiology
  2. Admission within 96 hours of ictus
  3. Aged between 21 and 75 years
  4. A speaker of Chinese (Mandarin or Cantonese)
  5. Informed consent from patients or their legally acceptable representatives

Exclusion criteria

  1. History of previous cerebrovascular disease or neurological disease other than intracranial aneurysm
  2. History of neurosurgical operation prior to ictus
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01038193

Contact: George KC Wong (852) 26321316
Contact: Shirley Chiu (852) 26322624

China, Hong Kong
Prince of Wales Hospital Recruiting
Hong Kong, Hong Kong, China, 852
Contact: George KC Wong    (852)26322624      
Contact: Shirley Chiu    (852)26321316      
Principal Investigator: George KC Wong         
Sponsors and Collaborators
Chinese University of Hong Kong
Principal Investigator: George KC Wong Division of Neurosurgery, CUHK
  More Information

No publications provided by Chinese University of Hong Kong

Additional publications automatically indexed to this study by Identifier (NCT Number):

Responsible Party: George KC Wong, Professor (Clinical), Chinese University of Hong Kong Identifier: NCT01038193     History of Changes
Other Study ID Numbers: GW004
Study First Received: December 22, 2009
Last Updated: February 2, 2015
Health Authority: Hong Kong: Joint CUHK-NTEC Clinical Research Ethics Committee

Keywords provided by Chinese University of Hong Kong:
Cognition, subarachnoid hemorrhage.

Additional relevant MeSH terms:
Cognition Disorders
Subarachnoid Hemorrhage
Brain Diseases
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders
Intracranial Hemorrhages
Mental Disorders
Nervous System Diseases
Pathologic Processes
Vascular Diseases processed this record on March 30, 2015