Study for the Liquid Chromatography-mass Spectrometry (LC-MS/MS) Assessment of Oxidative DNA Damage in Relation to Antioxidant Usage
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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The purpose of this study is to evaluate the basis for the reported good effects of antioxidant supplementation. A blood test using Mass Spectrometry will measure DNA damage which is expected to decrease with antioxidant administration and therefore decrease the risk of cancer.
Condition or disease
Dietary Supplement: 1 tablet composed of antioxidants and minerals
In this pilot study, the overall purpose is to establish the molecular basis for the hypothesis that oxidative stress is a risk factor for cancer. This will be achieved by establishing base line levels of oxidative DNA damage in a population of healthy individuals before and after taking antioxidant and mineral supplements for 8 weeks.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Health male or female non-melanoma patients or volunteers
18 years or older with a life expectancy greater than 6 months
Willing to provide pre and post blood samples to measure five DNA modifications in white blood cells
Willing to participate in a one tablet a day eight week supplement program and to record the ingestion of the supplement on a participant calendar
Must have never smoked or has not smoked for at least 6 months
Informed of the investigational nature of the study, is able to provide informed consent and has signed thee informed consent form
Patients/healthy volunteers not meeting all of the above selection criteria.
Patients/healthy volunteers who have a history of kidney stones within the last 5 years.
Any participant with life threatening conditions including but not limited to cardiac failure, congestive heart failure, unstable coronary artery disease, uncontrolled hypertension, poorly controlled diabetes mellitus, kidney and liver disease,severe metabolic disorders and advanced cancer
Patients not willing to comply with protocol requirements