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Effect of Turmeric on Pruritus in Hemodialysis Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01037595
Recruitment Status : Completed
First Posted : December 23, 2009
Last Update Posted : May 14, 2013
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study is to see whether turmeric can be effective in treatment of pruritus in hemodialysis patients.

Condition or disease Intervention/treatment Phase
End Stage Renal Failure Drug: turmeric Drug: placebo Early Phase 1

Detailed Description:
pruritus is a common in hemodialysis patients and many treatment recommended for it . as turmeric has anti-inflammatory , anti-cytokine and anti-oxidant effect it may effective in treatment of uremic pruritus. thus we compared turmeric with placebo in this study

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Study Start Date : September 2010
Primary Completion Date : October 2010
Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dialysis Itching
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: turmeric
turmeric 500 mg tid orally for 8 weeks
Drug: turmeric
turmeric 500 md tid orally for 8 weeks
Drug: turmeric
500 mg tid orally for 8 weeks
Placebo Comparator: plasebo
placebo tid orally for 8 weeks
Drug: placebo
placebo 3 time orally for 8 weeks

Outcome Measures

Primary Outcome Measures :
  1. improvement in pruritus [ Time Frame: 6 mo ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Hemodialysis for more than 3 months
  • More than 18 years old
  • Pruritus

Exclusion Criteria:

  • Use other treatment for pruritus
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01037595

Iran, Islamic Republic of
Shiraz University Hemodialysis Center
Shiraz, Fars, Iran, Islamic Republic of, 098
Sponsors and Collaborators
Shiraz University of Medical Sciences
More Information

Responsible Party: Maryam Pakfetrat, associated professor of shiraz Shiraz University of Medical Sciences, Shiraz University of Medical Sciences
ClinicalTrials.gov Identifier: NCT01037595     History of Changes
Other Study ID Numbers: 3441
First Posted: December 23, 2009    Key Record Dates
Last Update Posted: May 14, 2013
Last Verified: May 2013

Keywords provided by Maryam Pakfetrat, Shiraz University of Medical Sciences:

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Failure, Chronic
Kidney Diseases
Urologic Diseases
Renal Insufficiency, Chronic
Turmeric extract
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs