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Effect of Turmeric on Pruritus in Hemodialysis Patients

This study has been completed.
Information provided by (Responsible Party):
Maryam Pakfetrat, Shiraz University of Medical Sciences Identifier:
First received: December 22, 2009
Last updated: May 12, 2013
Last verified: May 2013
The purpose of this study is to see whether turmeric can be effective in treatment of pruritus in hemodialysis patients.

Condition Intervention Phase
End Stage Renal Failure
Drug: turmeric
Drug: placebo
Early Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Maryam Pakfetrat, Shiraz University of Medical Sciences:

Primary Outcome Measures:
  • improvement in pruritus [ Time Frame: 6 mo ]

Enrollment: 60
Study Start Date: September 2010
Study Completion Date: December 2010
Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: turmeric
turmeric 500 mg tid orally for 8 weeks
Drug: turmeric
turmeric 500 md tid orally for 8 weeks
Drug: turmeric
500 mg tid orally for 8 weeks
Placebo Comparator: plasebo
placebo tid orally for 8 weeks
Drug: placebo
placebo 3 time orally for 8 weeks

Detailed Description:
pruritus is a common in hemodialysis patients and many treatment recommended for it . as turmeric has anti-inflammatory , anti-cytokine and anti-oxidant effect it may effective in treatment of uremic pruritus. thus we compared turmeric with placebo in this study

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Hemodialysis for more than 3 months
  • More than 18 years old
  • Pruritus

Exclusion Criteria:

  • Use other treatment for pruritus
  Contacts and Locations
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Please refer to this study by its identifier: NCT01037595

Iran, Islamic Republic of
Shiraz University Hemodialysis Center
Shiraz, Fars, Iran, Islamic Republic of, 098
Sponsors and Collaborators
Shiraz University of Medical Sciences
  More Information

Responsible Party: Maryam Pakfetrat, associated professor of shiraz Shiraz University of Medical Sciences, Shiraz University of Medical Sciences Identifier: NCT01037595     History of Changes
Other Study ID Numbers: 3441
Study First Received: December 22, 2009
Last Updated: May 12, 2013

Keywords provided by Maryam Pakfetrat, Shiraz University of Medical Sciences:

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Failure, Chronic
Renal Insufficiency, Chronic
Kidney Diseases
Urologic Diseases
Turmeric extract
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs processed this record on May 25, 2017