"Association Splitting" in Obsessive-Compulsive Disorder (OCD)
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|ClinicalTrials.gov Identifier: NCT01035242|
Recruitment Status : Completed
First Posted : December 18, 2009
Last Update Posted : March 25, 2015
|Condition or disease||Intervention/treatment||Phase|
|Obsessive-Compulsive Disorder||Behavioral: "association splitting" Behavioral: cognitive remediation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||156 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||"Association Splitting" Compared With Cognitive Remediation (CR) in Obsessive-compulsive Disorder (OCD): a Randomized Controlled Trial|
|Study Start Date :||March 2009|
|Actual Primary Completion Date :||July 2012|
|Actual Study Completion Date :||July 2012|
Experimental: "association splitting"
Association splitting (6 sessions) delivered by psychologists.
Behavioral: "association splitting"
"Association splitting" is a cognitive intervention which aims at reducing obsessive thoughts. Association splitting is based on the so called fan effect (Anderson, 1974) and aims at reducing the strength of obsessive cognitions. For this purpose core intrusive thoughts are identified with the patient (such as "cancer - illness") and the patient is encouraged to find non-OCD associations that are (semantically or phonologically) related to the OCD cognition (such as "cancer - (zodiac) sign", "cancer - great crab"). To strengthen the novel connections, these associations are elaborated by the use of pictures, music, or smells. By enhancing OC-unrelated associations it is assumed that the influence of OC-related concepts is weakened.
Active Comparator: cognitive remediation
CogPack training(6 sessions) delivered by either psychologists or psychology students at an advanced master level.
Behavioral: cognitive remediation
Computerized cognitive remediation (CogPack training). A fixed sequence is administered, which covers a wide range of neuropsychological exercises involving memory, reasoning, selective attention and psychomotor speed. The difficulty level for each patient is adapted automatically depending on to the subject's performance on prior exercises. At the end of each session, the patient receives individual feedback on his or her performance. To match with association splitting, six sessions are administered. Each session lasts approximately 45-60 minutes.
- Total score of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) [ Time Frame: 8 weeks, 6 months ]
- Obsession subscore of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the total score of the Obsessive-Compulsive Inventory (OCI-R) [ Time Frame: 8 weeks, 6 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01035242
|University Medical Center Hamburg Eppendorf|
|Hamburg, Germany, 20246|
|Principal Investigator:||Lena Jelinek, PhD||Universitätsklinikum Hamburg-Eppendorf|
|Principal Investigator:||Steffen Moritz, PhD||Universitätsklinikum Hamburg-Eppendorf|