Assessment of sTREM-1 as a Diagnostic Marker in Patients With Neutropenic Fever
The soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) was an established biomarker useful for infection in non-neutropenic patients. In this study, we tested sTREM-1 in the patients with neutropenic fever. Pro-calcitonin (PCT) and C-reactive protein (CRP) were also measured. We planned to investigate and explore the role of sTREM-1 in early diagnosis of infection in patients with neutropenic fever.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Assessment of sTREM-1 as a Diagnostic Marker in Patients With Neutropenic Fever|
|Study Start Date:||October 2008|
|Study Completion Date:||June 2009|
|Primary Completion Date:||June 2009 (Final data collection date for primary outcome measure)|
Patients with hematological malignancies developed neutropenia after chemotherapy. We checked the serum level of sTREM-1 in patients with neutropenic fever. Those patients were classified to 2 groups: documented infection or low likelihood of infection. Their sTREM-1 level was measured and was compared with other biomarker such as CRP and procalcitonin. The value of sTREM-1 for diagnosis of infection in patients with neutropenic fever was thus evaluated.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01034059
|Principal Investigator:||Szu-Chun Hsu, MD||Department of Laboratory Medicine, National Taiwan University Hospital and College of Medicine, Taipei|