N-methyl Glycine (Sarcosine) for the Treatment of Obsessive Compulsive Disorder (OCD)
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Several lines of evidence implicate glutamatergic dysfunction in the pathophysiology of obsessive compulsive disorder (OCD). Sarcosine, also known as N-methylglycine, is an endogenous antagonist of glycine transporter-I (GlyT-I), which potentiates glycine's action at the glycine site of N-methyl-D-aspartate (NMDA) receptors. In this 10-week open-label trial, we examined the efficacy and safety of sarcosine treatment in OCD patients.
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Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
a primary OCD according to DSM-IV
at least 1 year's duration of OC symptoms and a minimum severity score of ≥16 on Yale-Brown Obsessive Compulsive Scale
drug naïve at study entry or
being free from psychotropic medication for at least 8 weeks at study entry,or
inadequately responded to ongoing psychotropic medications at study entry (defined by a Y-BOCS score of ≧16 despite treatment with maximum tolerated dose of a SRI medication for at least 8 weeks)
patients with moderate to severe depression defined by a 21-item Hamilton Depression Rating Scale score of >17,
a history of bipolar disorder, schizophrenia, schizoaffective disorder, or other psychosis as defined by DSM-IV, or if they were at significant risk of suicide, and
with clinically significant organic disease including cardiovascular, hepatic, pulmonary, neurologic, metabolic, or renal disease