QT Dispersion in Patients With Systemic Lupus Erythematosus (SLE)
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|ClinicalTrials.gov Identifier: NCT01031797|
Recruitment Status : Completed
First Posted : December 15, 2009
Last Update Posted : December 15, 2009
|Condition or disease|
Objective: Patients with systemic lupus erythematosus (SLE) have increased cardiovascular morbidity and mortality. Although autopsy studies have documented that the heart is affected in most SLE patients, clinical manifestations occur in less than 10%. QT dispersion is a new parameter that can be used to assess homogeneity of cardiac repolarization and autonomic function. We compared the increase in QT dispersion in SLE patients with high disease activity and mild or moderate disease activity.
Methods: One hundred twenty-four patients with SLE were enrolled in the study. Complete history and physical exam, ECG, echocardiography, exercise test and SLE disease activity index (SLEDAI) were recorded. Twenty patients were excluded on the basis of our exclusion criteria. The patients were divided to two groups based on SLEDAI: 54 in the high-score group (SLEDAI >10) and 50 in the low-score group (SLEDAI <10).
|Study Type :||Observational|
|Actual Enrollment :||124 participants|
|Observational Model:||Case Control|
|Official Title:||QT Dispersion in Patients With Systemic Lupus Erythematosus: the Impact of Disease Activity|
|Study Start Date :||January 2008|
|Actual Primary Completion Date :||March 2009|
|Actual Study Completion Date :||March 2009|
High SLE disease activity score
SLE patient with low score
- QT dispersion
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01031797
|Iran, Islamic Republic of|
|Shiraz University of Medical Sciences|
|Shiraz, Fars, Iran, Islamic Republic of|