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Chronic Alcohol and Brain Stress Circuit Response

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01031264
First Posted: December 14, 2009
Last Update Posted: July 30, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Information provided by (Responsible Party):
Rajita Sinha, Yale University
  Purpose
Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol relapse. This study will provide a greater understanding of the mechanism by which stress and alcohol consumption interacts to influence development of compulsive alcohol seeking and vulnerability to stress-induced drinking, and the results will have significant implications for the development of new prevention and treatment interventions for alcoholism.

Condition
Stress Alcoholism

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Chronic Alcohol and Brain Stress Circuit Response

Resource links provided by NLM:


Further study details as provided by Rajita Sinha, Yale University:

Primary Outcome Measures:
  • Assess differences in reactivity to cue imagery [ Time Frame: 2 years from start of study ]
    Physiological measures will be collected (heart rate, blood levels), self-reports of emotional states completed & alcohol taste task performed


Estimated Enrollment: 120
Study Start Date: January 2009
Study Completion Date: December 2014
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts
Social drinkers

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   21 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
social drinkers
Criteria

Inclusion Criteria:

  • ages 21-50
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01031264


Locations
United States, Connecticut
Yale Stress Center
New Haven, Connecticut, United States, 06519
Sponsors and Collaborators
Yale University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Investigators
Principal Investigator: Rajita Sinha, PhD Yale University
  More Information

Responsible Party: Rajita Sinha, Professor, Yale University
ClinicalTrials.gov Identifier: NCT01031264     History of Changes
Other Study ID Numbers: 0706002821
R01AA013892 ( U.S. NIH Grant/Contract )
First Submitted: December 10, 2009
First Posted: December 14, 2009
Last Update Posted: July 30, 2015
Last Verified: July 2015

Keywords provided by Rajita Sinha, Yale University:
social drinkers

Additional relevant MeSH terms:
Alcoholism
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders