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Chronic Alcohol and Brain Stress Circuit Response

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ClinicalTrials.gov Identifier: NCT01031264
Recruitment Status : Completed
First Posted : December 14, 2009
Last Update Posted : July 30, 2015
Sponsor:
Collaborator:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Information provided by (Responsible Party):
Rajita Sinha, Yale University

Brief Summary:
Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol relapse. This study will provide a greater understanding of the mechanism by which stress and alcohol consumption interacts to influence development of compulsive alcohol seeking and vulnerability to stress-induced drinking, and the results will have significant implications for the development of new prevention and treatment interventions for alcoholism.

Condition or disease
Stress Alcoholism

Study Type : Observational
Estimated Enrollment : 120 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Chronic Alcohol and Brain Stress Circuit Response
Study Start Date : January 2009
Actual Primary Completion Date : December 2014
Actual Study Completion Date : December 2014

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort
Social drinkers



Primary Outcome Measures :
  1. Assess differences in reactivity to cue imagery [ Time Frame: 2 years from start of study ]
    Physiological measures will be collected (heart rate, blood levels), self-reports of emotional states completed & alcohol taste task performed



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Ages Eligible for Study:   21 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
social drinkers
Criteria

Inclusion Criteria:

  • ages 21-50

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01031264


Locations
United States, Connecticut
Yale Stress Center
New Haven, Connecticut, United States, 06519
Sponsors and Collaborators
Yale University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Investigators
Principal Investigator: Rajita Sinha, PhD Yale University

Responsible Party: Rajita Sinha, Professor, Yale University
ClinicalTrials.gov Identifier: NCT01031264     History of Changes
Other Study ID Numbers: 0706002821
R01AA013892 ( U.S. NIH Grant/Contract )
First Posted: December 14, 2009    Key Record Dates
Last Update Posted: July 30, 2015
Last Verified: July 2015

Keywords provided by Rajita Sinha, Yale University:
social drinkers

Additional relevant MeSH terms:
Alcoholism
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders