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Chronic Alcohol and Brain Stress Circuit Response

This study has been completed.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Information provided by (Responsible Party):
Rajita Sinha, Yale University Identifier:
First received: December 10, 2009
Last updated: July 28, 2015
Last verified: July 2015
Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol relapse. This study will provide a greater understanding of the mechanism by which stress and alcohol consumption interacts to influence development of compulsive alcohol seeking and vulnerability to stress-induced drinking, and the results will have significant implications for the development of new prevention and treatment interventions for alcoholism.

Stress Alcoholism

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Chronic Alcohol and Brain Stress Circuit Response

Resource links provided by NLM:

Further study details as provided by Rajita Sinha, Yale University:

Primary Outcome Measures:
  • Assess differences in reactivity to cue imagery [ Time Frame: 2 years from start of study ]
    Physiological measures will be collected (heart rate, blood levels), self-reports of emotional states completed & alcohol taste task performed

Estimated Enrollment: 120
Study Start Date: January 2009
Study Completion Date: December 2014
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Social drinkers


Ages Eligible for Study:   21 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
social drinkers

Inclusion Criteria:

  • ages 21-50
  Contacts and Locations
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Please refer to this study by its identifier: NCT01031264

United States, Connecticut
Yale Stress Center
New Haven, Connecticut, United States, 06519
Sponsors and Collaborators
Yale University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Principal Investigator: Rajita Sinha, PhD Yale University
  More Information

Responsible Party: Rajita Sinha, Professor, Yale University Identifier: NCT01031264     History of Changes
Other Study ID Numbers: 0706002821
R01AA013892 ( US NIH Grant/Contract Award Number )
Study First Received: December 10, 2009
Last Updated: July 28, 2015

Keywords provided by Rajita Sinha, Yale University:
social drinkers

Additional relevant MeSH terms:
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders processed this record on June 26, 2017