Chronic Alcohol and Brain Stress Circuit Response

This study has been completed.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Information provided by (Responsible Party):
Rajita Sinha, Yale University Identifier:
First received: December 10, 2009
Last updated: July 28, 2015
Last verified: July 2015
Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol relapse. This study will provide a greater understanding of the mechanism by which stress and alcohol consumption interacts to influence development of compulsive alcohol seeking and vulnerability to stress-induced drinking, and the results will have significant implications for the development of new prevention and treatment interventions for alcoholism.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Chronic Alcohol and Brain Stress Circuit Response

Resource links provided by NLM:

Further study details as provided by Yale University:

Primary Outcome Measures:
  • Assess differences in reactivity to cue imagery [ Time Frame: 2 years from start of study ] [ Designated as safety issue: No ]
    Physiological measures will be collected (heart rate, blood levels), self-reports of emotional states completed & alcohol taste task performed

Estimated Enrollment: 120
Study Start Date: January 2009
Study Completion Date: December 2014
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Social drinkers


Ages Eligible for Study:   21 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
social drinkers

Inclusion Criteria:

  • ages 21-50
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01031264

United States, Connecticut
Yale Stress Center
New Haven, Connecticut, United States, 06519
Sponsors and Collaborators
Yale University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Principal Investigator: Rajita Sinha, PhD Yale University
  More Information

No publications provided

Responsible Party: Rajita Sinha, Professor, Yale University Identifier: NCT01031264     History of Changes
Other Study ID Numbers: 0706002821, R01AA013892
Study First Received: December 10, 2009
Last Updated: July 28, 2015
Health Authority: United States: Institutional Review Board

Keywords provided by Yale University:
social drinkers processed this record on November 27, 2015