Pharmacogenetics of Propofol and Depth of Anesthesia
Propofol, (2,6-diisopropylphenol) is a short-acting anesthetic drug used for induction and maintenance of anesthesia.
The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous EEG and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination.
Our hypothesis is that there is an individual requirement of Propofol plasma concentration depending on genetic differences in drug elimination.
200 patients, ASA classification 1, planned for elective surgery of a duration of at least 30 minutes will be included in this study.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Effect of Pharamocogenetices on Anesthesia Induction With Propofol|
- EEG pattern in correlation to clinical anesthesia [ Time Frame: 20120101 ] [ Designated as safety issue: No ]EEG pattern in correlation to clinical anesthesia
|Study Start Date:||January 2010|
|Study Completion Date:||February 2013|
|Primary Completion Date:||February 2013 (Final data collection date for primary outcome measure)|
|200 patients,ASA 1|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01029379
|Department of Anesthesia and Intensive Care|