Pharmacogenetics of Propofol and Depth of Anesthesia

This study has been completed.
Information provided by (Responsible Party):
Anna Oscarsson, University Hospital, Linkoeping Identifier:
First received: December 9, 2009
Last updated: March 1, 2013
Last verified: March 2013

Propofol, (2,6-diisopropylphenol) is a short-acting anesthetic drug used for induction and maintenance of anesthesia.

The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous EEG and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination.

Our hypothesis is that there is an individual requirement of Propofol plasma concentration depending on genetic differences in drug elimination.

200 patients, ASA classification 1, planned for elective surgery of a duration of at least 30 minutes will be included in this study.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Effect of Pharamocogenetices on Anesthesia Induction With Propofol

Resource links provided by NLM:

Further study details as provided by University Hospital, Linkoeping:

Primary Outcome Measures:
  • EEG pattern in correlation to clinical anesthesia [ Time Frame: 20120101 ] [ Designated as safety issue: No ]
    EEG pattern in correlation to clinical anesthesia

Enrollment: 100
Study Start Date: January 2010
Study Completion Date: February 2013
Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
200 patients,ASA 1


Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
200 patients, ASA classification 1 planned for elective surgery of at least 30 minutes duration

Inclusion Criteria:

  • Healthy caucasian patents,
  • (ASAclassification 1) planned for elective surgery,
  • with body mass index 20-30,
  • free from analgetic drug > 12 hours prior to anesthesia

Exclusion Criteria:

  • Pregnancy,
  • Smoking,
  • allergy to propofol or peanuts,
  • alcohol abuse,
  • non-caucasian
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Please refer to this study by its identifier: NCT01029379

Department of Anesthesia and Intensive Care
Kalmar, Sweden
Sponsors and Collaborators
University Hospital, Linkoeping
  More Information

No publications provided by University Hospital, Linkoeping

Additional publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Anna Oscarsson, Dr, University Hospital, Linkoeping Identifier: NCT01029379     History of Changes
Other Study ID Numbers: Progen1 
Study First Received: December 9, 2009
Last Updated: March 1, 2013
Health Authority: Sweden: Medical Products Agency

Keywords provided by University Hospital, Linkoeping:
depth of anesthesia
Depth of anesthesia in correlation to plasma concentrations of propofol

Additional relevant MeSH terms:
Anesthetics, General
Anesthetics, Intravenous
Central Nervous System Agents
Central Nervous System Depressants
Hypnotics and Sedatives
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses processed this record on February 08, 2016