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Cerebrovascular Autoregulation During Sepsis

This study has been completed.
Information provided by (Responsible Party):
Patrick Schramm, Johannes Gutenberg University Mainz Identifier:
First received: December 8, 2009
Last updated: April 12, 2013
Last verified: April 2013
The aim of the study is to correlate the dynamic cerebrovascular autoregulation by patients with sepsis with a sepsis-associated delirium.

Condition Intervention
Sepsis Delirium Other: no interventions

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Dynamic Cerebrovascular Autoregulation During Sepsis and Sepsis-associated Delirium

Resource links provided by NLM:

Further study details as provided by Patrick Schramm, Johannes Gutenberg University Mainz:

Primary Outcome Measures:
  • Disturbed cerebrovascular autoregulation correlates with sepsis associated delir [ Time Frame: 1 year ]
    The Index of autoregulation (Mx) was measured and correlated with the clinical incidence of a sepsis associated delir

Secondary Outcome Measures:
  • Correlation between inflammatory parameters and disturbed cerebrovascular autoregulation [ Time Frame: 1 year ]
  • Correlation between inflammatory parameters and sepsis-associated delirium [ Time Frame: 1 year ]

Enrollment: 30
Study Start Date: December 2009
Study Completion Date: March 2011
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
All patients with sepsis defined by actually sepsis guidelines
Other: no interventions
No interventions


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All patients at intensive care unit were screened to symptoms that definate sepsis

Inclusion Criteria:

  • clinical symptoms of sepsis, severe sepsis and septic shock
  • possibility for measurement of transcranial doppler ultrasound
  • age over 18 years

Exclusion Criteria:

  • preexisting cerebrovascular disease
  • preexisting immunological disease
  • traumatic brain injury
  • intracranial infectious disease
  • pregnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT01029080

University medical centre Mainz
Mainz, Germany, 55131
Sponsors and Collaborators
Johannes Gutenberg University Mainz
  More Information

Responsible Party: Patrick Schramm, Senior Physician, Johannes Gutenberg University Mainz Identifier: NCT01029080     History of Changes
Other Study ID Numbers: 837.435.08
Study First Received: December 8, 2009
Last Updated: April 12, 2013

Keywords provided by Patrick Schramm, Johannes Gutenberg University Mainz:
Brain, blood flow
Measurement techniques, flow velocity waveform analysis
Monitoring, intensive care
transcranial doppler ultrasound (TCD)
Cerebrovascular autoregulation
sepsis-associated delir

Additional relevant MeSH terms:
Systemic Inflammatory Response Syndrome
Pathologic Processes
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Neurocognitive Disorders
Mental Disorders processed this record on August 18, 2017