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Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

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ClinicalTrials.gov Identifier: NCT01025024
Recruitment Status : Completed
First Posted : December 3, 2009
Last Update Posted : December 3, 2009
Sponsor:
Collaborators:
Korea Healthcare Technology R&D Project
Korea Advanced Institute of Science and Technology
Information provided by:
Chungnam National University

Brief Summary:
A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

Condition or disease Intervention/treatment
Single-nucleotide Polymorphism (SNP) for Glaucoma Genetic: SNP analysis of the DNA

Detailed Description:
Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Study Type : Observational
Actual Enrollment : 1224 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients Patients, A Single-nucleotide Polymorphism(SNP)Analysis for Primary Open Angle Glaucoma
Study Start Date : January 2007
Actual Primary Completion Date : October 2009
Actual Study Completion Date : November 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Glaucoma
U.S. FDA Resources

Group/Cohort Intervention/treatment
POAG group
Elevated intraocular pressure normal open angle glaucomatous optic nerve head abnormality glaucomatous visual field defect
Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
Normal control
Normal intraocular pressure No optic disc abnormality No visual field defect No significant ocular and systemic disease
Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample



Primary Outcome Measures :
  1. genotyping for the SNP associated with primary open angle glaucoma [ Time Frame: one year ]

Secondary Outcome Measures :
  1. genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns [ Time Frame: one year ]

Biospecimen Retention:   Samples With DNA
Peripheral blood sample


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Ages Eligible for Study:   30 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients with open angle glaucoma who visited glaocoma clinic of departemtn of Ophtalmology, Chungnam National University Hospital, Daejeon, south Korea
Criteria

Inclusion Criteria:

  • Clinical diagnosis of primary open angle glaucoma

Exclusion Criteria:

  • Primary open angle glaucoma combined with congenital ocular disease
  • Primary open angel glaucoma combined with other ocular disease
  • Significant systemic disease other than systemic hypertension and diabetes

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01025024


Locations
Korea, Republic of
Chungnam National University Hospital
Daejeon, Korea, Republic of, 301-721
Sponsors and Collaborators
Chungnam National University
Korea Healthcare Technology R&D Project
Korea Advanced Institute of Science and Technology
Investigators
Principal Investigator: Chang-sik Kim, professor Department of Ophthalmology, Chungnam National University Hospital
Study Chair: Changwon Kang, professor Korea Advanced Institute of Science and Technology
Study Director: Kyunglan Kim Department of Biological Sciences, Korea Advanced Institute of Science and Technology

Responsible Party: Chang-sik Kim, professor, Department of Ophthalmology, College of Medicine, Chungnam National University
ClinicalTrials.gov Identifier: NCT01025024     History of Changes
Other Study ID Numbers: CNUH81510-886
A080587 ( Other Grant/Funding Number: Korea Healthcare Technology R&D Project )
First Posted: December 3, 2009    Key Record Dates
Last Update Posted: December 3, 2009
Last Verified: December 2009

Keywords provided by Chungnam National University:
SNP
single-nucleotide polymorphism
glaucoma
primary open angle glaucoma

Additional relevant MeSH terms:
Glaucoma
Genetic Diseases, Inborn
Ocular Hypertension
Eye Diseases