Non-invasive Measurement of Hemoglobin in Retinal Arteries
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|ClinicalTrials.gov Identifier: NCT01025011|
Recruitment Status : Unknown
Verified November 2009 by Triemli Hospital.
Recruitment status was: Recruiting
First Posted : December 3, 2009
Last Update Posted : December 3, 2009
|Condition or disease||Intervention/treatment|
|Healthy Subjects Anemia||Device: Fundus photography, cubital blood draw|
To our knowledge no tool exists that allows for direct collection of hemoglobin data in the eye. In many eye diseases (especially diabetic and hypertensive retinopathy as well as in retinal vessel occlusions) retinal circulation is modified. Knowing hemoglobin concentration on the site of the pathology will give us further information about the pathogenesis of this diseases and may provide a new possibility in therapy.
The purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries. Healthy volunteers from the eye clinic and pregnant otherwise healthy patients of the gynecological department of the Triemli Hospital, Zurich, as well as anemic gynecological patients that show up for a check-up are included.
Hemoglobin will be quantified by a blood draw of a cubital vein. Using a Fundus Camera (Nidek AFC-230) pictures of the fundus will be taken from each study patient. Afterwards the study investigator selects a retinal artery of interest which will be used for measuring the hemoglobin concentration. Intensity of the green channel of the camera chip is determined with the aid of the law of Lambert-Beer.
Absolute Hemoglobin concentration is calculated in relation to the vessel volume.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Non- Invasive Measurement of the Absolute Hemoglobin Value in the Retinal Arteries of Anemic and Healthy Subjects Using a New Approach|
|Study Start Date :||March 2008|
|Estimated Primary Completion Date :||June 2010|
|Estimated Study Completion Date :||June 2010|
healthy volunteers, anemic patients
healthy volunteers from the eye and gynecology department pregnant patients with anemia
Device: Fundus photography, cubital blood draw
blood draw from a cubital vein to measure hemoglobin concentration taking a fundus photography with a Nidek AFC-230, no pupil dilation needed
- Correlation of hemoglobin concentration measured in a cubital vein and in a non invasive way using hemoglobinometry in the retinal veins [ Time Frame: 2.5 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01025011
|Contact: Yves Robert, Prof MD||+41 44 466 ext firstname.lastname@example.org|
|Stadtpital Zürich, Triemli Hospital||Recruiting|
|Zürich, Switzerland, 8063|
|Contact: Yves Robert, Prof MD +41 44 466 ext 3200 email@example.com|
|Principal Investigator:||Yves Robert, Prof MD||Triemli Hospital|