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Role of Angiotensin II in Insulin-induced Microvascular Activity

This study has been completed.
Information provided by:
Maastricht University Medical Center Identifier:
First received: November 30, 2009
Last updated: December 1, 2009
Last verified: December 2009
In this study we hypothesize infusion of Angiotensin II improves the insulin-induced microvascular dilatation and therefore insulin-mediated glucose uptake. Objectives: Does infusion of Angiotensin II increase insulin-mediated glucose uptake via enhanced insulin-mediated microvascular function in healthy subjects?

Condition Intervention
Insulin Sensitivity Microcirculation Drug: Angiotensin II Drug: Phenylephrine Drug: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Role of Angiotensin II in Insulin-induced Microvascular Activity

Resource links provided by NLM:

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • functional recruitment of capillaries in the skin [ Time Frame: January 2009 ]

Secondary Outcome Measures:
  • perfused capillary density in the nailfold [ Time Frame: January 2009 ]
  • Endothelium- (in)dependent vasodilatation of finger skin microcirculation [ Time Frame: January 2006 ]
  • Insulin sensitivity [ Time Frame: January 2009 ]

Enrollment: 18
Study Start Date: October 2006
Estimated Study Completion Date: November 2009
Primary Completion Date: November 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Sham Comparator: Placebo
Drug: Placebo
Experimental: Angiotensin II
Angiotensin II
Drug: Angiotensin II
Angiotensin II
Active Comparator: Phenylephrine
Drug: Phenylephrine


Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

1.18-60 years 2.Caucasian 3.Blood pressure <140/90 mmHg.

Exclusion Criteria:

  1. Obesity (BMI>27kg/m2)
  2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
  3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
  4. Smoking
  5. Alcohol use >4U/day
  6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
  7. Pregnancy
  8. Wearing contact lenses
  Contacts and Locations
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Please refer to this study by its identifier: NCT01024543

Maastricht University Medical Centre
Maastricht, P.o. Box 5800, Netherlands, Netherlands, 6202 AZ
Sponsors and Collaborators
Maastricht University Medical Center
Study Chair: CDA Stehouwer, Prof Maastricht University Medical Centre
  More Information

Responsible Party: Prof. CDA Stehouwer, Maastricht University Medical Centre Identifier: NCT01024543     History of Changes
Other Study ID Numbers: MEC 06-2-074
Study First Received: November 30, 2009
Last Updated: December 1, 2009

Keywords provided by Maastricht University Medical Center:
Angiotensin II

Additional relevant MeSH terms:
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Angiotensin II
Cardiotonic Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Vasoconstrictor Agents
Nasal Decongestants
Respiratory System Agents
Adrenergic alpha-1 Receptor Agonists
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Protective Agents
Serine Proteinase Inhibitors
Protease Inhibitors
Enzyme Inhibitors processed this record on August 21, 2017