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Trial record 5 of 75 for:    PEELING SKIN SYNDROME

Central Corneal Thickness in Glaucoma

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ClinicalTrials.gov Identifier: NCT01023997
Recruitment Status : Completed
First Posted : December 2, 2009
Last Update Posted : May 12, 2014
Sponsor:
Information provided by (Responsible Party):
AGP Konstas, Aristotle University Of Thessaloniki

Brief Summary:
The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate the value of corneal thickness in the diagnosis and management of glaucoma.

Condition or disease
Exfoliation Syndrome

Detailed Description:
To compare the central corneal thickness measurement in patients with exfoliation, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate the value of corneal thickness in the diagnosis and management of glaucoma. Prospective study in progress. Randomly selected patients undergo a comprehensive ophthalmic exam which includes 2 separate pachymetry measurements in 2 different examinations at the same time of the day (10:00 am) with 3 different pachymeters. The values obtained are correlated with a number of other glaucoma parameters. A thinner cornea may represent a specific attribute and an additional risk factor for patients with exfoliation. Evaluation of corneal thickness is an important exam in the management of patients with exfoliation.

Study Type : Observational
Actual Enrollment : 700 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Central Corneal Thickness in Patients With Exfoliation Syndrome, Exfoliative Glaucoma, Exfoliative Glaucoma, Primary Open-angle Glaucoma and Ocular Hypertension
Study Start Date : January 2008
Actual Primary Completion Date : January 2013
Actual Study Completion Date : January 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Glaucoma

Group/Cohort
primary open-angle glaucoma
ocular hypertension patients
normal controls
Exfoliation patients
patients with exfoliation syndrome or exfoliative glaucoma



Primary Outcome Measures :
  1. central corneal thickness [ Time Frame: Morning measurement (10:00-11:00) ]

Secondary Outcome Measures :
  1. Visual field, scanning laser polarimetry [ Time Frame: 10:00-11:00 ]


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Ages Eligible for Study:   25 Years to 89 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
individuals with and without exfoliation
Criteria

Inclusion Criteria:

  • Exfoliation material on pupil
  • Intraocular pressure below 21 mm Hg without glaucomatous damage
  • Intraocular pressure above 21 mm Hg without glaucomatous damage
  • Raised intraocular pressure with glaucomatous damage

Exclusion Criteria:

  • Corneal disorders
  • History of trauma
  • Evidence of corneal abnormality that may influence IOP
  • Contact lens use
  • Corneal surgery

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01023997


Locations
Greece
Glaucoma Unit, 1st University Department of Ophthalmology
Thessaloniki, Greece, 546 36
Sponsors and Collaborators
Aristotle University Of Thessaloniki
Investigators
Study Director: Kostantinos Kaltsos, MD, PhD 1st University Dept of Ophthalmology

Responsible Party: AGP Konstas, Professor in Ophthalmology, Aristotle University Of Thessaloniki
ClinicalTrials.gov Identifier: NCT01023997     History of Changes
Other Study ID Numbers: A3502
First Posted: December 2, 2009    Key Record Dates
Last Update Posted: May 12, 2014
Last Verified: May 2014

Keywords provided by AGP Konstas, Aristotle University Of Thessaloniki:
corneal thickness
exfoliation

Additional relevant MeSH terms:
Syndrome
Glaucoma
Exfoliation Syndrome
Disease
Pathologic Processes
Ocular Hypertension
Eye Diseases
Iris Diseases
Uveal Diseases