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Correlation Between Various Inflammatory Markers and Vascular Inflammation Measured by 18FDG-PET

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01022684
First Posted: December 1, 2009
Last Update Posted: February 22, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Korea University
  Purpose

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Various inflammatory markers such as LpPLA2,MCP-2 and hsCRP are well-known prognostic factors for the cardiovascular event.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between various inflammatory markers and vascular inflammation detected by 18FDG-PET.


Condition Intervention
Atherosclerosis Other: Cross section study

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Correlation of Inflammatory Markers Such as LpPLA2,MCP-1 and hsCRP for Predicting Vascular Inflammation; Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography

Resource links provided by NLM:


Further study details as provided by Korea University:

Primary Outcome Measures:
  • Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET [ Time Frame: 12 weeks ]

Secondary Outcome Measures:
  • Correlation between various inflammatory markers and atherosclerosis measured by carotid intima media thickness [ Time Frame: 12 weeks ]

Biospecimen Retention:   Samples Without DNA
Whole blood, serum

Enrollment: 150
Study Start Date: December 2009
Study Completion Date: January 2010
Primary Completion Date: January 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy patients Other: Cross section study
This is not intervention study. The purpose of the study is to examine the relationship between various inflammatory markers and PET imaging at the cross section setting

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 88 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy participatin who underwent a medical health check in the health promotion center in Korea Guro University
Criteria

Inclusion Criteria:

  • Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
  • Diabetes
  • Stage 2 hypertension (resting blood pressure, ≥160/100 mmHg)
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as NSIAD and statin
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01022684


Locations
Korea, Republic of
Hye Jin Yoo
Seoul, Korea, Republic of
Sponsors and Collaborators
Korea University
Investigators
Principal Investigator: Kyung Mook Choi, MD.PhD Korea University
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Kyung Mook Choi, Korea University
ClinicalTrials.gov Identifier: NCT01022684     History of Changes
Other Study ID Numbers: KOSEF20546
First Submitted: November 27, 2009
First Posted: December 1, 2009
Last Update Posted: February 22, 2010
Last Verified: November 2009

Keywords provided by Korea University:
atherosclerosis
vascular inflammation
LpPLA2
hsCRP
MCP-1
18FDG-PET

Additional relevant MeSH terms:
Inflammation
Atherosclerosis
Pathologic Processes
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases