This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Correlation Between Various Inflammatory Markers and Vascular Inflammation Measured by 18FDG-PET

This study has been completed.
Information provided by:
Korea University Identifier:
First received: November 27, 2009
Last updated: February 19, 2010
Last verified: November 2009

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Various inflammatory markers such as LpPLA2,MCP-2 and hsCRP are well-known prognostic factors for the cardiovascular event.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between various inflammatory markers and vascular inflammation detected by 18FDG-PET.

Condition Intervention
Atherosclerosis Other: Cross section study

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Correlation of Inflammatory Markers Such as LpPLA2,MCP-1 and hsCRP for Predicting Vascular Inflammation; Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography

Resource links provided by NLM:

Further study details as provided by Korea University:

Primary Outcome Measures:
  • Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET [ Time Frame: 12 weeks ]

Secondary Outcome Measures:
  • Correlation between various inflammatory markers and atherosclerosis measured by carotid intima media thickness [ Time Frame: 12 weeks ]

Biospecimen Retention:   Samples Without DNA
Whole blood, serum

Enrollment: 150
Study Start Date: December 2009
Study Completion Date: January 2010
Primary Completion Date: January 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy patients Other: Cross section study
This is not intervention study. The purpose of the study is to examine the relationship between various inflammatory markers and PET imaging at the cross section setting


Ages Eligible for Study:   20 Years to 88 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy participatin who underwent a medical health check in the health promotion center in Korea Guro University

Inclusion Criteria:

  • Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
  • Diabetes
  • Stage 2 hypertension (resting blood pressure, ≥160/100 mmHg)
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as NSIAD and statin
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01022684

Korea, Republic of
Hye Jin Yoo
Seoul, Korea, Republic of
Sponsors and Collaborators
Korea University
Principal Investigator: Kyung Mook Choi, MD.PhD Korea University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Kyung Mook Choi, Korea University Identifier: NCT01022684     History of Changes
Other Study ID Numbers: KOSEF20546
Study First Received: November 27, 2009
Last Updated: February 19, 2010

Keywords provided by Korea University:
vascular inflammation

Additional relevant MeSH terms:
Pathologic Processes
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases processed this record on September 19, 2017