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Preconditioning Volatile Anesthesia in Liver Surgery

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ClinicalTrials.gov Identifier: NCT01021228
Recruitment Status : Completed
First Posted : November 26, 2009
Last Update Posted : November 26, 2009
Sponsor:
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to compare the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.

Condition or disease
Anesthesia

Detailed Description:
Comparing the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.

Study Design

Study Type : Observational
Actual Enrollment : 257 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Preconditioning is Indeed Protective
Study Start Date : August 2008
Primary Completion Date : October 2009
Study Completion Date : October 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Anesthesia
U.S. FDA Resources

Groups and Cohorts

Group/Cohort
group1
continuous volatile anesthesia (sevoflurane) during the liver resection
group2
continuous intravenous anesthesia (propofol) during the liver resection
group3
preconditioning volatile anesthesia (sevoflurane) 30 minutes before ischemia (inflow occlusion)


Outcome Measures

Primary Outcome Measures :
  1. peak ALT and AST levels representing the ischemia-reperfusion injury [ Time Frame: post-operative ]

Secondary Outcome Measures :
  1. length of hospital stay, length of ICU stay, blood loss and morbidity (post-operative complications) [ Time Frame: post-operative ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Consecutive patients were included undergoing any type of liver resection with inflow occlusion for benign as well as malign diseases between January first, 2005 and December 31, 2007 in a single tertiary care center
Criteria

Inclusion Criteria:

  • > 18 years
  • benign and malign disease
  • any type of liver surgery
  • inflow occlusion during the liver surgery

Exclusion Criteria:

  • < 18 years
  • participation on other interventional and treatment randomized controlled trials,
  • trauma of the liver
  • liver cirrhosis
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01021228


Locations
Switzerland
Universtiy Hospital of Zurich, Department of Visceral and Transplantation Surgery
Zurich, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Investigators
Principal Investigator: Ksenija Slankamenac, med. pract Departement of Visceral and Transplantation
More Information

Responsible Party: Slankamenac Ksenija, med. pract, Department of Visceral and Transplantation Surgery
ClinicalTrials.gov Identifier: NCT01021228     History of Changes
Other Study ID Numbers: StV 18-2008
First Posted: November 26, 2009    Key Record Dates
Last Update Posted: November 26, 2009
Last Verified: November 2009

Keywords provided by University of Zurich:
Liver resection
Continuous volatile anesthesia
Continuous intravenous anesthesia
Preconditioning volatile anesthesia
Comparing three groups of anesthesia during the liver surgery according to their benefit on liver and outcome.

Additional relevant MeSH terms:
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs