Preconditioning Volatile Anesthesia in Liver Surgery

This study has been completed.
Information provided by:
University of Zurich Identifier:
First received: November 25, 2009
Last updated: NA
Last verified: November 2009
History: No changes posted
The purpose of this study is to compare the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Preconditioning is Indeed Protective

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • peak ALT and AST levels representing the ischemia-reperfusion injury [ Time Frame: post-operative ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • length of hospital stay, length of ICU stay, blood loss and morbidity (post-operative complications) [ Time Frame: post-operative ] [ Designated as safety issue: Yes ]

Enrollment: 257
Study Start Date: August 2008
Study Completion Date: October 2009
Primary Completion Date: October 2009 (Final data collection date for primary outcome measure)
continuous volatile anesthesia (sevoflurane) during the liver resection
continuous intravenous anesthesia (propofol) during the liver resection
preconditioning volatile anesthesia (sevoflurane) 30 minutes before ischemia (inflow occlusion)

Detailed Description:
Comparing the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Consecutive patients were included undergoing any type of liver resection with inflow occlusion for benign as well as malign diseases between January first, 2005 and December 31, 2007 in a single tertiary care center

Inclusion Criteria:

  • > 18 years
  • benign and malign disease
  • any type of liver surgery
  • inflow occlusion during the liver surgery

Exclusion Criteria:

  • < 18 years
  • participation on other interventional and treatment randomized controlled trials,
  • trauma of the liver
  • liver cirrhosis
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Please refer to this study by its identifier: NCT01021228

Universtiy Hospital of Zurich, Department of Visceral and Transplantation Surgery
Zurich, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Principal Investigator: Ksenija Slankamenac, med. pract Departement of Visceral and Transplantation
  More Information

No publications provided

Responsible Party: Slankamenac Ksenija, med. pract, Department of Visceral and Transplantation Surgery Identifier: NCT01021228     History of Changes
Other Study ID Numbers: StV 18-2008
Study First Received: November 25, 2009
Last Updated: November 25, 2009
Health Authority: Switzerland: Ethikkommission

Keywords provided by University of Zurich:
Liver resection
Continuous volatile anesthesia
Continuous intravenous anesthesia
Preconditioning volatile anesthesia
Comparing three groups of anesthesia during the liver surgery according to their benefit on liver and outcome.

Additional relevant MeSH terms:
Central Nervous System Agents
Central Nervous System Depressants
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses processed this record on November 24, 2015