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Effects of N-acetylcysteine on Pulmonary Function in High-risk Patients Undergoing Off-pump Coronary Bypass Surgery

This study has been completed.
Information provided by:
Yonsei University Identifier:
First received: November 25, 2009
Last updated: NA
Last verified: November 2009
History: No changes posted
The purpose of this study is to study the effects of N-acetylcysteine on pulmonary function in high-risk patients undergoing off-pump coronary bypass surgery.

Condition Intervention Phase
Coronary Artery Occlusion Drug: N-acetylcysteine, saline Phase 4

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Yonsei University:

Enrollment: 48
Arms Assigned Interventions
Placebo Comparator: N-acetylcysteine , saline Drug: N-acetylcysteine, saline
Inject 100 mg/kg of N-acetylcysteine or the equivalent amount of saline for 15 minutes before the skin incision, then continuously inject 40 mg/kg/day of N-acetylcysteine or the equivalent amount of saline during the next 24 hours.


Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Adult patients with Euroscore ≥ 5

Exclusion Criteria:

  • Patients in need of emergency surgery,acute renal failure patients, kidney transplanted patients, patients injected with NAC 5days before planned surgery
  Contacts and Locations
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Please refer to this study by its identifier: NCT01021163

Korea, Republic of
Severance Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Yonsei University
  More Information

Responsible Party: Young Lan Kwak / Professor, Anesthesiology and Pain Medicine Identifier: NCT01021163     History of Changes
Other Study ID Numbers: 4-2007-0236
Study First Received: November 25, 2009
Last Updated: November 25, 2009

Additional relevant MeSH terms:
Coronary Occlusion
Coronary Disease
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Antiviral Agents
Anti-Infective Agents
Respiratory System Agents
Free Radical Scavengers
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs
Antidotes processed this record on June 22, 2017