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The Effect of Osteopathic Manual Therapy on the Vascular Supply to the Lower Extremity, Function and Symptoms of Subjects With Knee Osteoarthritis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2009 by Nova Scotia Health Authority.
Recruitment status was:  Recruiting
Information provided by:
Nova Scotia Health Authority Identifier:
First received: November 24, 2009
Last updated: December 15, 2009
Last verified: December 2009
The purpose of this study is to determine if the use of osteopathic manual therapy can influence the vascular supply to the knee, knee range of motion, balance and knee pain, in a group of subjects with knee osteoarthritis. It is also the objective of this study to determine if there is a difference between the osteopathic evaluation and the combination of an osteopathic evaluation and treatment.

Condition Intervention
Knee Osteoarthritis
Other: Osteopathic evaluation
Other: Osteopathic evaluation with treatment

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Outcomes Assessor)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Nova Scotia Health Authority:

Primary Outcome Measures:
  • The superficial femoral artery blood flow parameters (systolic peak velocity, end diastolic velocity, pulsatility index (PI) and resistance index (RI), and the arterial diameter) [ Time Frame: 10 minutes ]

Secondary Outcome Measures:
  • The knee flexion active range of motion, balance and pain (VAS) [ Time Frame: 10 minutes ]

Estimated Enrollment: 40
Study Start Date: December 2009
Estimated Study Completion Date: March 2010
Estimated Primary Completion Date: March 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Sham Comparator: Osteopathic evaluation Other: Osteopathic evaluation
evaluation of movement and tissue mobility
Experimental: Osteopathic evaluation with treatment
osteopathic evaluation of motion and tissue mobility followed by osteopathic manual therapy release of the tight or restricted tissues
Other: Osteopathic evaluation with treatment
osteopathic evaluation followed by osteopathic manual therapy release of tissues identified as tight or restricted


Ages Eligible for Study:   50 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Radiographic-confirmed knee osteoarthritis

Exclusion Criteria:

  • Subjects who are unable to ambulate independently (without an aid) and safely the distance of a city block
  • Subjects who have an uncontrolled medical condition (e.g. heart (angina) or respiratory condition (asthma))
  • Subjects who have a neurological condition (e.g. Parkinson's, Multiple Sclerosis)
  • Subjects who have both knees affected by osteoarthritis and have had previous surgery to both knees
  • Subjects who have knee OA in only one knee and that knee has had previous knee surgery
  • Subjects who have previous vascular surgery to either leg
  Contacts and Locations
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Please refer to this study by its identifier: NCT01020591

Contact: Wendy M Jardine, MScPT 902 429 6218

Canada, Nova Scotia
Capital District Health Authority Recruiting
Halifax, Nova Scotia, Canada, B3H 1V7
Contact: Wendy Jardine   
Principal Investigator: Wendy M Jardine, MScPT         
Sponsors and Collaborators
Nova Scotia Health Authority
Principal Investigator: Wendy M Jardine, MScPT Nova Scotia Health Authority
  More Information

Responsible Party: Wendy Jardine, Capital District Health Authority Identifier: NCT01020591     History of Changes
Other Study ID Numbers: CDHA-RS/2010-227
Study First Received: November 24, 2009
Last Updated: December 15, 2009

Keywords provided by Nova Scotia Health Authority:
knee osteoarthritis
manual therapy

Additional relevant MeSH terms:
Osteoarthritis, Knee
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases processed this record on April 27, 2017