4D Image-guided Adaptive Radiotherapy for Lung Cancer: Patient Image Acquisition
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|ClinicalTrials.gov Identifier: NCT01018147|
Recruitment Status : Completed
First Posted : November 23, 2009
Last Update Posted : February 8, 2016
|Condition or disease||Intervention/treatment||Phase|
|Lung Cancer||Procedure: 4-dimensional computed tomography||Not Applicable|
- Quantify the magnitude and distribution of inter- and intrafraction anatomic variations, including the temporal stability of the tumor/respiration signal correlation.
- Improve the acquisition and reconstruction of 4D CT scan images by advancing the 4D CT scan data collection process and evaluating 4D CT scan image reconstruction using different respiratory inputs.
- Quantify the uncertainty of deformable image-registration algorithms.
- Develop and investigate the efficacy of inter- and intrafraction probabilistic planning-based 4D image-guided adaptive radiotherapy (IGART) strategies for clinical application.
- Determine the expected geometric, dosimetric, and radiobiological improvements from the 4D IGART system.
OUTLINE: Patients undergo insertion of ≥ 1 small radio-opaque marker into (or in the vicinity of) the primary lesion or suspect lymph nodes via bronchoscopy. X-rays are performed to document the position of the markers.
Patients undergo 4D CT scan before each radiotherapy session and once a week after a radiotherapy session. Patients also undergo x-ray imaging before and during radiotherapy, optical and internal marker motion recording before and after radiotherapy, and audiovisual feedback during radiotherapy.
Patients undergo image-guided adapted radiotherapy based on these data.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||22 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||4D Image-guided Adaptive Radiotherapy for Lung Cancer: Patient Image Acquisition|
|Study Start Date :||September 2006|
|Actual Primary Completion Date :||April 2012|
|Actual Study Completion Date :||October 2015|
Experimental: CT Imaging
Patients undergo 4-D, 4-dimensional computed tomography, CT imaging prior to radiotherapy sessions and once a week at the end of treatment.
Procedure: 4-dimensional computed tomography
Undergo 4-D CT imaging
Other Name: 4D-CT
- At least 1 mm reduction in overall systematic error corresponding with ≥ 2 mm CTV-PTV margin reduction [ Time Frame: Up to 7 years ]
- At least 5 Gy reduction in mean lung dose [ Time Frame: up to 7 years ]
- At least 5% reduction in absolute pneumonitis risk (≥ grade 2) [ Time Frame: up to 7 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01018147
|Principal Investigator:||Jeffrey F. Williamson, PhD||Massey Cancer Center|