4D Image-guided Adaptive Radiotherapy for Lung Cancer: Patient Image Acquisition
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
|Official Title:||4D Image-guided Adaptive Radiotherapy for Lung Cancer: Patient Image Acquisition|
- At least 1 mm reduction in overall systematic error corresponding with ≥ 2 mm CTV-PTV margin reduction [ Time Frame: Up to 7 years ] [ Designated as safety issue: No ]
- At least 5 Gy reduction in mean lung dose [ Time Frame: up to 7 years ] [ Designated as safety issue: No ]
- At least 5% reduction in absolute pneumonitis risk (≥ grade 2) [ Time Frame: up to 7 years ] [ Designated as safety issue: No ]
|Study Start Date:||September 2006|
|Study Completion Date:||October 2015|
|Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
Experimental: CT Imaging
Patients undergo 4-D, 4-dimensional computed tomography, CT imaging prior to radiotherapy sessions and once a week at the end of treatment.
Procedure: 4-dimensional computed tomography
Undergo 4-D CT imaging
Other Name: 4D-CT
- Quantify the magnitude and distribution of inter- and intrafraction anatomic variations, including the temporal stability of the tumor/respiration signal correlation.
- Improve the acquisition and reconstruction of 4D CT scan images by advancing the 4D CT scan data collection process and evaluating 4D CT scan image reconstruction using different respiratory inputs.
- Quantify the uncertainty of deformable image-registration algorithms.
- Develop and investigate the efficacy of inter- and intrafraction probabilistic planning-based 4D image-guided adaptive radiotherapy (IGART) strategies for clinical application.
- Determine the expected geometric, dosimetric, and radiobiological improvements from the 4D IGART system.
OUTLINE: Patients undergo insertion of ≥ 1 small radio-opaque marker into (or in the vicinity of) the primary lesion or suspect lymph nodes via bronchoscopy. X-rays are performed to document the position of the markers.
Patients undergo 4D CT scan before each radiotherapy session and once a week after a radiotherapy session. Patients also undergo x-ray imaging before and during radiotherapy, optical and internal marker motion recording before and after radiotherapy, and audiovisual feedback during radiotherapy.
Patients undergo image-guided adapted radiotherapy based on these data.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01018147
|Principal Investigator:||Jeffrey F. Williamson, PhD||Massey Cancer Center|