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Role of Oral Glutathione in Skin Whitening

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ClinicalTrials.gov Identifier: NCT01016080
Recruitment Status : Completed
First Posted : November 18, 2009
Last Update Posted : November 18, 2009
Sponsor:
Information provided by:
Chulalongkorn University

Study Description
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Brief Summary:
Oral and intravenous glutathione have been used widely to whiten the skin. The investigators tested this hypothesis by giving oral glutathione for 4 weeks to medical students.

Condition or disease Intervention/treatment Phase
Skin Whitening Drug: glutathione Drug: placebo Phase 1

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Glutathione as an Oral Whitening Agent: a Randomized, Double-blind, Placebo-controlled Study
Study Start Date : February 2009
Actual Primary Completion Date : May 2009
Actual Study Completion Date : June 2009

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Drug Information available for: Glutathione

Arms and Interventions
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Arm Intervention/treatment
Active Comparator: oral glutathione
glutathione, 500 mg, taken orally twice daily
 Drug: glutathione
250 mg capsules, twice daily, orally
Placebo Comparator: placebo capsules
identical-appearing placebo capsules
 Drug: placebo
250 mg capsules, twice daily, orally


Outcome Measures
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Primary Outcome Measures :
  1. Skin melanin index [ Time Frame: 4 weeks ]

Eligibility Criteria
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Ages Eligible for Study:   18 Years to 25 Years   (Adult)
Sexes Eligible for Study:   All
Criteria

Inclusion Criteria:

  • Healthy medical students

Exclusion Criteria:

  • history of skin cancer, especially melanoma
  • consumption of any preparations containing glutathione within 1 month of enrollment
  • pigmentary disorders or any dermatoses
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01016080


Locations
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Thailand
King Chulalongkorn Memorial Hospital
Bangkok, Thailand, 10330
Sponsors and Collaborators
Chulalongkorn University
More Information
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Responsible Party: Pravit Asawanonda, Chulalongkorn University
ClinicalTrials.gov Identifier: NCT01016080    
Other Study ID Numbers: COA840/2008
First Posted: November 18, 2009    Key Record Dates
Last Update Posted: November 18, 2009
Last Verified: November 2009
Keywords provided by Chulalongkorn University:
glutathione
melanin
whitening
UV spots
skin pigment