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Role of Oral Glutathione in Skin Whitening

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01016080
First Posted: November 18, 2009
Last Update Posted: November 18, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Chulalongkorn University
  Purpose
Oral and intravenous glutathione have been used widely to whiten the skin. The investigators tested this hypothesis by giving oral glutathione for 4 weeks to medical students.

Condition Intervention Phase
Skin Whitening Drug: glutathione Drug: placebo Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Glutathione as an Oral Whitening Agent: a Randomized, Double-blind, Placebo-controlled Study

Resource links provided by NLM:


Further study details as provided by Chulalongkorn University:

Primary Outcome Measures:
  • Skin melanin index [ Time Frame: 4 weeks ]

Enrollment: 60
Study Start Date: February 2009
Study Completion Date: June 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: oral glutathione
glutathione, 500 mg, taken orally twice daily
Drug: glutathione
250 mg capsules, twice daily, orally
Placebo Comparator: placebo capsules
identical-appearing placebo capsules
Drug: placebo
250 mg capsules, twice daily, orally

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 25 Years   (Adult)
Sexes Eligible for Study:   All
Criteria

Inclusion Criteria:

  • Healthy medical students

Exclusion Criteria:

  • history of skin cancer, especially melanoma
  • consumption of any preparations containing glutathione within 1 month of enrollment
  • pigmentary disorders or any dermatoses
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01016080


Locations
Thailand
King Chulalongkorn Memorial Hospital
Bangkok, Thailand, 10330
Sponsors and Collaborators
Chulalongkorn University
  More Information

Responsible Party: Pravit Asawanonda, Chulalongkorn University
ClinicalTrials.gov Identifier: NCT01016080     History of Changes
Other Study ID Numbers: COA840/2008
First Submitted: November 17, 2009
First Posted: November 18, 2009
Last Update Posted: November 18, 2009
Last Verified: November 2009

Keywords provided by Chulalongkorn University:
glutathione
melanin
whitening
UV spots
skin pigment