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Safety and Tolerability Trial of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor Hematopoietic Stem Cell Transplant

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01012492
First Posted: November 13, 2009
Last Update Posted: December 5, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Leslie Kean, Seattle Children's Hospital
  Purpose
The primary objective of the study is to determine the safety and tolerability when adding abatacept to acute Graft versus Host Disease in transplants for malignant diseases using unrelated donor bone marrow or peripheral blood stem cell grafts.

Condition Intervention Phase
AML ALL Undifferentiated Leukemia Biphenotypic Leukemia Refractory Anemia Refractory Anemia With Ringed Sideroblasts Refractory Cytopenia With Multilineage Dysplasia Refractory Cytopenia With Multilineage Dysplasia and Ringed Sideroblasts Refractory Anemia With Excess Blasts-1 (5-10% Blasts) Refractory Anemia With Excess Blasts-2 (10-20% Blasts) Myelodysplastic Syndrome, Unclassified MDS Associated With Isolated Del (5q) Drug: Abatacept Phase 2

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Safety and Tolerability Trial of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor Hematopoietic Stem Cell Transplant

Resource links provided by NLM:


Further study details as provided by Leslie Kean, Seattle Children's Hospital:

Primary Outcome Measures:
  • Percentage of Participants With Grade III-IV Acute GVHD by Day 100. [ Time Frame: Day 100 post-transplant ]
    Grade III-IV Acute GVHD by Day 100. The incidence of Gr III-IV acute GVHD was measured by the modified Glucksburg scale.


Secondary Outcome Measures:
  • Percentage of Participants With Grades III-IV Acute GVHD at 2 Years [ Time Frame: 2 years after transplant ]
    The rates of Grades III-IV acute GVHD were measured at 2 years according to standard Glucksberg criteria, which was 10%.

  • Immunology [ Time Frame: 3 years ]
  • Protective Immunity [ Time Frame: 3 years after transplant ]

Enrollment: 11
Study Start Date: November 2009
Study Completion Date: January 2013
Primary Completion Date: November 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Abatacept
Participants will receive one of two standard myeloablative conditioning regimens for their stem cell transplant, and will receive an aGvHD prophylaxis regimen including cyclosporine, methotrexate, and abatacept.
Drug: Abatacept
Participants will receive one of two standard myeloablative conditioning regimens for their stem cell transplant, and will receive an aGvHD prophylaxis regimen including cyclosporine, methotrexate, and abatacept.

Detailed Description:

Acute Graft versus Host Disease (aGvHD) is the most deadly complication facing children who have allogeneic hematopoietic stem cell transplant (HSCT). aGvHD occurs, in large part, because the T cells in the bone marrow graft do not "accept" the presence of the transplant recipient's cells, and mount a severe, debilitating, and often deadly attack against the recipient, striking the skin, the liver, and the gastrointestinal track, most prominently. For patients receiving bone marrow from an unrelated donor, the rate of aGvHD can reach as high as 80%, with up to half of patients dying from this complication. These serious outcomes occur despite our best efforts at aGvHD prevention. Given the lack of success in preventing aGvHD with current therapies, novel therapies to prevent this disease are desperately needed.

In this study, we plan to test a novel drug to prevent aGvHD. This drug, known as abatacept, specifically blocks the activation pathway critical to T cell function known as "T cell costimulation." In particular, it blocks the CD28-mediated costimulation pathway that is critical for optimal T cell activation and proliferation. My research group has done extensive pre-clinical work with this compound. Our work has demonstrated its efficacy in inducing immune tolerance after transplantation in both mouse models and primate models. In addition, patient trials have demonstrated that blocking CD28-directed T cell costimulation can prevent T cell-mediated diseases, including rheumatoid arthritis and psoriasis, and can improve solid organ transplant acceptance. Abatacept is currently FDA approved for use in rheumatoid arthritis. Given this drug's safety and efficacy profile, we have been granted an IND-exemption from the FDA for the inclusion of abatacept in a GvHD-prevention strategy.

This is a safety and tolerability study of the addition of abatacept to a GvHD-prophylaxis regimen. Thus, the primary objective of the study is to determine the safety and tolerability of the addition of abatacept to aGvHD prophylaxis in transplants for malignant hematologic disease using unrelated donor bone marrow or peripheral blood stem cell grafts.

Three secondary objectives will also be addressed:

  1. We will estimate the incidence and severity of aGvHD in patients receiving the abatacept-based protocol.
  2. We will determine the immune phenotype of donor cells in patients receiving abatacept.
  3. We will determine the ability of donor T-cells in patients receiving abatacept to respond to both polyclonal and recipient-specific immune stimulation.

These secondary objectives will allow us to determine the impact of abatacept-containing GvHD prevention on both T cell alloreactivity and on T cell-mediated protective immunity.

This study is for patients older than 12 who have been diagnosed with high-risk leukemia and for whom an unrelated bone marrow transplant is planned. We plan to enroll 10 patients on the study, over a 1-year period from the opening of the trial. Of these ten patients, at least five will be pediatric patients; the other five may be from adult patients taken care of by Winship Cancer Center physicians. All clinical study coordination and biologic studies will be performed by CHOA personnel.

Participants will receive one of two standard myeloablative conditioning regimens for their stem cell transplant, and will receive an aGvHD prophylaxis regimen including cyclosporine, methotrexate, and abatacept. They will have immunologic analysis for 1 year after transplant and clinical analysis for 3 years after transplant.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   12 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Patients with AML, with or without a history of myelodysplastic syndrome in one of the following categories.

    (a) Patients in first complete remission with high-risk features

  2. Patients with ALL, in either of the following categories:

    1. In 2nd or greater complete remission (complete remission is defined as > 5% blasts in marrow)
    2. Delayed 1st CR-Failure to achieve complete remission after a single round of induction therapy
  3. Patients with undifferentiated or biphenotypic leukemia in 1st or greater complete remission.
  4. Patients with Myelodysplastic Syndrome(s) with an IPSS score of >1.5 and <10% blasts in the bone marrow at the time of transplant. These conditions will include:

    1. Refractory anemia
    2. Refractory anemia with ringed sideroblasts
    3. Refractory cytopenia with multilineage dysplasia
    4. Refractory cytopenia with multilineage dysplasia and ringed sideroblasts
    5. Refractory anemia with excess blasts-1 (5-10% blasts)
    6. Refractory anemia with excess blasts-2 (10-20% blasts)
    7. Myelodysplastic syndrome, unclassified
    8. MDS associated with isolated del (5q)
    9. Patients diagnosed with AML in CR1 after an initial diagnosis of MDS.
  5. Age 12 years or older.
  6. No prior allogeneic transplant
  7. Karnofsky performance score or Lansky Play-Performance of at least 80.
  8. Signed informed consent for adults and for minors the provision of pediatric assent and parental permission.

Exclusion Criteria:

  1. Age <12 years old.
  2. Patients requiring >2 courses of induction chemotherapy to achieve remission status.
  3. HIV infection
  4. Tuberculosis Infection
  5. Chronic Obstructive Pulmonary Disease
  6. Pregnancy (positive serum b-HCG) or breastfeeding
  7. Creatinine clearance or nuclear medicine GFR of < 50 mL/min
  8. Cardiac ejection fraction < 50%
  9. bilirubin > 2 × upper limit of normal or ALT > 4 × upper limit of normal or unresolved veno-occlusive disease.
  10. Pulmonary disease with FVC, FEV1 or DLCO parameters <45% predicted (corrected for hemoglobin) or O2 saturation <92% on room air.
  11. Karnofsky performance score or Lansky Play-Performance Scale <80
  12. Uncontrolled viral, bacterial, or fungal infection at the time of study enrollment
  13. Availability of a willing and fully MHC-matched related donor.
  14. Positive cytotoxic recipient-donor cross-match or positive HLA antibody screen against donor-disparate antigens.
  15. Any active infection.
  16. Unable to obtain informed consent.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01012492


Locations
United States, Washington
Seattle Children's Research Institute, Ben Towne Center for Childhood Cancer Research
Seattle, Washington, United States, 98101
Sponsors and Collaborators
Seattle Children's Hospital
Investigators
Principal Investigator: Leslie Kean, MD, PhD Emory University
  More Information

Publications:
Responsible Party: Leslie Kean, Assistant Professor, Seattle Children's Hospital
ClinicalTrials.gov Identifier: NCT01012492     History of Changes
Other Study ID Numbers: IRB00024488
Abatacept ( Other Identifier: Other )
First Submitted: November 11, 2009
First Posted: November 13, 2009
Results First Submitted: November 25, 2015
Results First Posted: September 15, 2017
Last Update Posted: December 5, 2017
Last Verified: October 2017

Keywords provided by Leslie Kean, Seattle Children's Hospital:
cancer
leukemia
transplant
bone marrow

Additional relevant MeSH terms:
Leukemia
Anemia
Myelodysplastic Syndromes
Preleukemia
Anemia, Refractory
Anemia, Refractory, with Excess of Blasts
Leukemia, Myeloid, Acute
Neoplasms by Histologic Type
Neoplasms
Hematologic Diseases
Bone Marrow Diseases
Precancerous Conditions
Leukemia, Myeloid
Abatacept
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents