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Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) (NOUBASST)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01010165
Recruitment Status : Completed
First Posted : November 9, 2009
Last Update Posted : October 26, 2012
Information provided by (Responsible Party):
University Hospital, Grenoble

Brief Summary:

Septic arthritis is a frequent, potentially disabling and/or life-threatening disease. To diagnose a septic arthritis is a complex procedure, first because of numerous differential diagnoses (such as crystal arthritis), second because of poor sensitivity of initial gram staining (for example after untimely antibiotic therapy).

This protocol will use SELDI-TOF as a tool to analyse joint fluid of patients with various acute, polymorphonuclear-rich arthritis, as to determine specific and sensitive new biomarkers of a septic origin.

Such biomarkers will allow rapid diagnosis of septic arthritis in the first hours of admission.

Condition or disease
Acute Arthritis

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Study Type : Observational
Actual Enrollment : 89 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Caractérisation de Nouveaux Biomarqueurs de l'Arthrite Septique Par Technique SELDI-TOF
Study Start Date : October 2009
Actual Primary Completion Date : October 2012
Actual Study Completion Date : October 2012

Resource links provided by the National Library of Medicine

septic arthritis
crystal arthritis
rheumatismal disease

Biospecimen Retention:   Samples Without DNA
joint fluid proteom

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients from the Grenoble University Hospital

Inclusion Criteria:

  • acute arthritis (onset not more than 7 days ago)
  • joint fluid leukocyte count : more than 2000/mm3, more than 50% polymorphonuclear

Exclusion Criteria:

  • none (apart from unability to accept inclusion)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01010165

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University Hospital
Grenoble, France, 38000
Sponsors and Collaborators
University Hospital, Grenoble
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Principal Investigator: olivier epaulard, MD, PhD University Hospital, Grenoble

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Responsible Party: University Hospital, Grenoble Identifier: NCT01010165     History of Changes
Other Study ID Numbers: 0916
2009-A00810-57 ( Registry Identifier: RCB )
First Posted: November 9, 2009    Key Record Dates
Last Update Posted: October 26, 2012
Last Verified: December 2011
Keywords provided by University Hospital, Grenoble:
acute arthritis
crystal arthritis
Additional relevant MeSH terms:
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Joint Diseases
Musculoskeletal Diseases