Cardiovascular Risk Factors After Renal Transplantation in Children and Adults (HENT)
|ClinicalTrials.gov Identifier: NCT01008306|
Recruitment Status : Unknown
Verified November 2009 by Oslo University Hospital.
Recruitment status was: Active, not recruiting
First Posted : November 5, 2009
Last Update Posted : November 5, 2009
Renal transplantation of children started in Norway in 1970.Since the beginning, >80% of renal transplants are provided from Living Donors(mainly parents), short pre-transplant dialysis time( median 4 months) and 50% of transplantations are performed before dialysis is needed.This gives good premises for graft survival and avoidance of detrimental effects of dialysis. However, renal transplanted children are subjected to an increased cardiovascular morbidity and mortality in adulthood due to consequences of chronic renal failure and immunosuppressive treatment.Cardiovascular death comprises 30-40% of death causes. In this cross-sectional study we evaluate cardiovascular risk factors in childhood- and also in young adults renal transplanted in childhood.
Focus is cardiorespiratory fitness using treadmill testing,24h BP measurements, anthropometrics including waist circumference,echocardiography,intima media thickness of carotids, glucose intolerance test.Participants are also requested to fill out physical activity recalls and Quality of life questionnaires.
|Condition or disease|
|Exercise Capacity Physical Activity Hypertension Overweight and Obesity Metabolic Syndrome|
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Official Title:||Outcome After Pediatric Renal Transplantation: Cardiorespiratory Fitness, Cardiovascular Risk Factors and Quality of Life|
|Study Start Date :||June 2007|
|Estimated Primary Completion Date :||June 2010|
Renal transplanted children and young adults
Renal transplanted children and adolescents (2-18yrs) transplanted between 1993-2006.
Renal transplanted young adults aged 20-35 yrs old, transplanted from 1983 onwards.
- other cardiovascular risk factors [ Time Frame: 2007-2010 ]
- hypertension [ Time Frame: 2007-2010 ]
- impaired glucose intolerance [ Time Frame: 2007-2010 ]
- left ventricular hypertrophy, [ Time Frame: 2007-2010 ]
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01008306
|Oslo University Hospital Rikshospitalet HF, Division of Pediatrics|
|Oslo, Norway, 0027|