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Cardiovascular Risk Factors After Renal Transplantation in Children and Adults (HENT)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2009 by Oslo University Hospital.
Recruitment status was:  Active, not recruiting
Norwegian Red Cross
Information provided by:
Oslo University Hospital Identifier:
First received: November 3, 2009
Last updated: November 4, 2009
Last verified: November 2009

Renal transplantation of children started in Norway in 1970.Since the beginning, >80% of renal transplants are provided from Living Donors(mainly parents), short pre-transplant dialysis time( median 4 months) and 50% of transplantations are performed before dialysis is needed.This gives good premises for graft survival and avoidance of detrimental effects of dialysis. However, renal transplanted children are subjected to an increased cardiovascular morbidity and mortality in adulthood due to consequences of chronic renal failure and immunosuppressive treatment.Cardiovascular death comprises 30-40% of death causes. In this cross-sectional study we evaluate cardiovascular risk factors in childhood- and also in young adults renal transplanted in childhood.

Focus is cardiorespiratory fitness using treadmill testing,24h BP measurements, anthropometrics including waist circumference,echocardiography,intima media thickness of carotids, glucose intolerance test.Participants are also requested to fill out physical activity recalls and Quality of life questionnaires.

Exercise Capacity
Physical Activity
Overweight and Obesity
Metabolic Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Outcome After Pediatric Renal Transplantation: Cardiorespiratory Fitness, Cardiovascular Risk Factors and Quality of Life

Resource links provided by NLM:

Further study details as provided by Oslo University Hospital:

Secondary Outcome Measures:
  • other cardiovascular risk factors [ Time Frame: 2007-2010 ]
  • hypertension [ Time Frame: 2007-2010 ]
  • impaired glucose intolerance [ Time Frame: 2007-2010 ]
  • left ventricular hypertrophy, [ Time Frame: 2007-2010 ]

Biospecimen Retention:   Samples Without DNA
Freezing of serum and plasma from study participants

Estimated Enrollment: 60
Study Start Date: June 2007
Estimated Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Renal transplanted children and young adults

Renal transplanted children and adolescents (2-18yrs) transplanted between 1993-2006.

Renal transplanted young adults aged 20-35 yrs old, transplanted from 1983 onwards.


Ages Eligible for Study:   2 Years to 38 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Renal transplanted children, adolescents and young adults transplanted in the period 1983-2006 in the same center (Oslo University Hospital, Rikshospitalet)

Inclusion Criteria:

  • Transplanted after 1983, functioning graft

Exclusion Criteria:

  • Patients in dialysis
  • In part of the study concerning treadmill testing: Age<8 years, orthopedic limitations
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Please refer to this study by its identifier: NCT01008306

Oslo University Hospital Rikshospitalet HF, Division of Pediatrics
Oslo, Norway, 0027
Sponsors and Collaborators
Oslo University Hospital
Norwegian Red Cross
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Oslo University Hospital, Rikshospitalet HF, Rikshospitalet HF, department of pediatrics Identifier: NCT01008306     History of Changes
Other Study ID Numbers: S-07245b
Study First Received: November 3, 2009
Last Updated: November 4, 2009

Keywords provided by Oslo University Hospital:
Cardiorespiratory fitness
physical activity
overweight and obesity
metabolic syndrome
Body composition

Additional relevant MeSH terms:
Metabolic Syndrome X
Vascular Diseases
Cardiovascular Diseases
Body Weight
Signs and Symptoms
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases processed this record on April 24, 2017