This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

A Novel Echocardiography Modality to Assess Left Ventricular Dyssynchrony

This study has been withdrawn prior to enrollment.
(investigator left the institution)
Information provided by (Responsible Party):
University of Missouri-Columbia Identifier:
First received: November 4, 2009
Last updated: October 3, 2016
Last verified: October 2016
The investigators hypothesize that the relation between mechanical and hemodynamic left ventricular dyssynchrony might better predict response to Cardiac Resynchronization Device(CRT) than currently existing echo indices.

Heart Failure

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Novel Echocardiography Modality to Assess Left Ventricular Dyssynchrony: Hemodynamic Assessment by 4D Segmental Ejection Fraction

Further study details as provided by University of Missouri-Columbia:

Primary Outcome Measures:
  • 4D echo is the best modality to measure systolic dyssynchrony index [ Time Frame: Two years ]

Enrollment: 0
Study Start Date: November 2008
Estimated Study Completion Date: May 2010
Estimated Primary Completion Date: May 2010 (Final data collection date for primary outcome measure)
CRT device
Patients with Cardiac Resynchronization Therapy(CRT) device implanted in the last 5 years will be studied by the new echo modality.Study doesn't involve acute device implantation.

Detailed Description:

Cardiac resynchronization therapy is emerging to be a highly effective treatment option for selected patients with symptomatic congestive heart failure on optimal medical therapy and evidence of left ventricular (LV) conduction delay and contraction dyssynchrony. It can improve quality of life and results in better survival in this selected group of patients. However, patients have different responses to CRT, and up to 30% of those implanted show no response at all. Ongoing trials, whether prospective or retrospective, have been trying to define best predictors of response to CRT and to measure ventricular dyssynchrony. Despite this, no single echo criterion to date can predict successful CRT over current guidelines.

In this study, we propose to compare LV muscle mechanical dyssynchrony assessment by speckle tracking to hemodynamic dyssynchrony assessment by 4D segmental ejection fraction (EF), a novel modality brought recently by University of Missouri Echocardiography laboratory.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients followed in cardiology clinic will be included.

Inclusion Criteria:

  • Cardiac Resynchronization Therapy(CRT) device implanted in the last 5 years.

Exclusion Criteria:

  • Acute decompensated congestive heart failure.
  • chronic permanent atrial fibrillation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01007981

Sponsors and Collaborators
University of Missouri-Columbia
Principal Investigator: Firas H El Sabbagh, MD University of Missouri-Columbia
  More Information

Responsible Party: University of Missouri-Columbia Identifier: NCT01007981     History of Changes
Other Study ID Numbers: 1124400
Study First Received: November 4, 2009
Last Updated: October 3, 2016
Individual Participant Data  
Plan to Share IPD: No

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases processed this record on June 22, 2017