Antibacterial Properties of Silicon Incorporated With Quaternary Ammonium Polyethylenimine Nanoparticles
|ClinicalTrials.gov Identifier: NCT01007240|
Recruitment Status : Unknown
Verified November 2009 by Hadassah Medical Organization.
Recruitment status was: Not yet recruiting
First Posted : November 4, 2009
Last Update Posted : November 4, 2009
The aim of this study is to evaluate the antibacterial activity of crosslinked quaternary ammonium polyethylenimine (PEI) nanoparticles incorporated at 1-2% w/w in a commercial soft liner material when compared to the commercial soft liner material.
The investigators' results in vitro showed a significant delay in bacterial growth.
Therefore, the investigators assume to have the same delay in vivo- on patients.
|Condition or disease||Intervention/treatment||Phase|
|Carcinoma of Head and Neck||Device: polyethylenimine (PEI) nanoparticles.||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||10 participants|
|Intervention Model:||Single Group Assignment|
|Official Title:||Clinical Study of the Antibacterial Properties of the Nano Particles Which Incorporated With the Soft Liner Silicone - in Obturators|
|Study Start Date :||January 2010|
|Estimated Primary Completion Date :||May 2010|
|Estimated Study Completion Date :||December 2010|
Experimental: soft liner with nano particles
the obturators of this patients will be relined with soft liner, with incorporated nano particles. after a week, the soft liner will be taken off, and will be checked for bacterial adhesion.
|Device: polyethylenimine (PEI) nanoparticles.|
- bacterial growth [ Time Frame: a week ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01007240
|Contact: anat b sharon, Msc, DMDfirstname.lastname@example.org|
|Principal Investigator:||anat b sharon, DMD, MSc||lecturer, department of maxillofacial rehabilitation, hadassah medical organiztion|