Antibacterial Properties of Silicon Incorporated With Quaternary Ammonium Polyethylenimine Nanoparticles
Recruitment status was: Not yet recruiting
The aim of this study is to evaluate the antibacterial activity of crosslinked quaternary ammonium polyethylenimine (PEI) nanoparticles incorporated at 1-2% w/w in a commercial soft liner material when compared to the commercial soft liner material.
The investigators' results in vitro showed a significant delay in bacterial growth.
Therefore, the investigators assume to have the same delay in vivo- on patients.
Carcinoma of Head and Neck
Device: polyethylenimine (PEI) nanoparticles.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Prevention
|Official Title:||Clinical Study of the Antibacterial Properties of the Nano Particles Which Incorporated With the Soft Liner Silicone - in Obturators|
- bacterial growth [ Time Frame: a week ] [ Designated as safety issue: Yes ]
|Study Start Date:||January 2010|
|Estimated Study Completion Date:||December 2010|
|Estimated Primary Completion Date:||May 2010 (Final data collection date for primary outcome measure)|
Experimental: soft liner with nano particles
the obturators of this patients will be relined with soft liner, with incorporated nano particles. after a week, the soft liner will be taken off, and will be checked for bacterial adhesion.
|Device: polyethylenimine (PEI) nanoparticles.|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01007240
|Principal Investigator:||anat b sharon, DMD, MSc||lecturer, department of maxillofacial rehabilitation, hadassah medical organiztion|