Study of Biomarkers in DNA Samples From Patients With Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia
RATIONALE: Studying samples of DNA from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research study is looking at biomarkers in DNA samples from patients with acute lymphoblastic leukemia or acute myeloid leukemia.
Genetic: gene expression analysis
Genetic: microarray analysis
Genetic: polymorphism analysis
|Study Design:||Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:||Genetic Polymorphisms in ALL Samples Submitted to Gene Array Analysis|
- Collection of DNA samples for use in analysis of a wide range of host factors influencing etiology and outcome of disease [ Designated as safety issue: No ]
- Host factors that can be determined at onset of treatment to predict outcome of chemotherapy, and thus modify the therapy administered [ Designated as safety issue: No ]
|Study Start Date:||April 2002|
|Estimated Primary Completion Date:||January 2100 (Final data collection date for primary outcome measure)|
- Collect DNA samples from patients with cytogenetically, well characterized, and uniformly treated acute lymphoblastic leukemia or acute myeloid leukemia for use in analysis of a wide range of host factors influencing etiology and outcome of the disease.
- Identify host factors that can be determined at onset of treatment to predict outcome of chemotherapy, and thus modify the therapy administered.
OUTLINE: Previously collected DNA samples are analyzed for polymorphisms at a variety of loci. Gene expression and expression profiles are correlated with genotype and therapy outcomes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01005277
|Study Chair:||Stella M. Davies, MBBS, PhD||Children's Hospital Medical Center, Cincinnati|