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Evaluation of Omeprazole Effect on Glaucoma

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2009 by Shahid Beheshti University of Medical Sciences.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01000220
First Posted: October 22, 2009
Last Update Posted: May 4, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Ophthalmic Research Center
Information provided by:
Shahid Beheshti University of Medical Sciences
  Purpose
Omeprazole is a safe drug listed in OTC drug due to its safety. It acts by irreversible inhibition of K/H ATP ase pump and also Na/K ATP ase, Na/H ATP ase.Considering these actions the effect of omeprazole on decreasing intra ocular pressure is an issue of debate.In this Randomized Clinical Trial conducted in labafinejad hospital, patients with glaucoma who need to take omeprazole due to GI problem are evaluated in two groups including placebo and drug users. The effect will be finally assessed.

Condition Intervention Phase
Glaucoma Drug: Omeprazole Drug: Placebo Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Evaluation of Omeprazole Effect on Glaucoma

Resource links provided by NLM:


Further study details as provided by Shahid Beheshti University of Medical Sciences:

Arms Assigned Interventions
Active Comparator: Omeprazole Drug: Omeprazole
Placebo Comparator: placebo Drug: Placebo

Detailed Description:
Omeprazole is a safe drug listed in OTC drug due to its safety. It acts by irreversible inhibition of K/H ATP ase pump and also Na/K ATP ase, Na/H ATP ase.Considering these actions the effect of omeprazole on decreasing intra ocular pressure is an issue of debate.In this Randomized Clinical Trial conducted in labafinejad hospital, patients with glaucoma who need to take omeprazole due to GI problem are evaluated in two groups including placebo and drug users. The effect will be finally assessed.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • patients with glaucoma
  • 18 to 70 years
  • POAG patients, Pseudoexfoliation
  • no history of other systemic disease
  • no history of intraocular intervention
  • no history of H2 blocker or PPI consumption during the past month consuming 2 or less topical anti-glaucoma medication
  • no present immune deficiency
  • no addiction habit

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01000220


Contacts
Contact: Yazdani Shahin, MD +982122585952 labbafi@hotmail.com

Locations
Iran, Islamic Republic of
Ophthalmic Research Center Recruiting
Tehran, Iran, Islamic Republic of, 166666
Contact: Shahin yazdani, MD    +98 21 22585952    labbafi@hotmail.com   
Sponsors and Collaborators
Shahid Beheshti University of Medical Sciences
Ophthalmic Research Center
  More Information

Responsible Party: Ophthalmic Research Center
ClinicalTrials.gov Identifier: NCT01000220     History of Changes
Other Study ID Numbers: 8735
First Submitted: July 7, 2009
First Posted: October 22, 2009
Last Update Posted: May 4, 2010
Last Verified: October 2009

Additional relevant MeSH terms:
Glaucoma
Ocular Hypertension
Eye Diseases
Omeprazole
Anti-Ulcer Agents
Gastrointestinal Agents
Proton Pump Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action


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