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Glucose-dependent Insulinotropic Polypeptide (GIP) and Lipid Metabolism

This study has been completed.
Information provided by:
Hvidovre University Hospital Identifier:
First received: October 20, 2009
Last updated: NA
Last verified: October 2009
History: No changes posted
The aim of this proposal is to examine whether endogenous GIP and exogenous GIP alone and in combination with insulin affect gastric emptying (GE), appetite, energy intake, energy expenditure (EE) and plasma levels of triglycerides (TAG), free fatty acids FFA) and glycerol in man.

Condition Intervention
Healthy Subjects Other: Incretin hormone - Glucose-dependent insulinotropic polypeptide (GIP)

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: On the Role of Glucose-dependent Insulinotropic Polypeptide, GIP, in Postprandial Metabolism in Humans

Resource links provided by NLM:

Further study details as provided by Hvidovre University Hospital:

Estimated Enrollment: 30
Study Start Date: August 2008
Study Completion Date: September 2009
Primary Completion Date: September 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy subjects
30 healthy subjects without family history of diabetes or gastrointestinal disease, a normal oral glucose tolerance test (OGTT) and no intake of medicine
Other: Incretin hormone - Glucose-dependent insulinotropic polypeptide (GIP)

two different dosages:

  • 0.8 pmol/kg/min
  • 1.5 pmol/kg/min for 300 minutes


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers

Inclusion Criteria:

  • Informed oral and written consent
  • Caucasians over the age of 18 years
  • Normal 75 g oral glucose tolerance test (OGTT)
  • Normal blood haemoglobin concentration
  • Normal plasma lipid profile

Exclusion Criteria:

  • First-degree relatives with diabetes and familial hypertriglyceridemia
  Contacts and Locations
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Please refer to this study by its identifier: NCT00999271

Hvidovre Hospital
Hvidovre, Denmark, 2650
Sponsors and Collaborators
Hvidovre University Hospital
  More Information

Responsible Party: University of Copenhagen Identifier: NCT00999271     History of Changes
Other Study ID Numbers: HD-2009-0025
Study First Received: October 20, 2009
Last Updated: October 20, 2009

Keywords provided by Hvidovre University Hospital:
Glucose-dependent insulinotropic polypeptide
gastric emptying
energy intake
lipid metabolism

Additional relevant MeSH terms:
Gastric Inhibitory Polypeptide
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Gastrointestinal Agents processed this record on September 21, 2017