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Glucose and Lipid Metabolism in Adolescents

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2009 by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
Recruitment status was:  Recruiting
Information provided by:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Identifier:
First received: October 20, 2009
Last updated: June 6, 2011
Last verified: October 2009
A 12 wk aerobic exercise program will reduce visceral, hepatic and intramyocellular fat accumulation and improve insulin sensitivity and glucose metabolism in obese sedentary Hispanic adolescents.

Condition Intervention
Insulin Sensitivity
Behavioral: Exercise

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Glucose and Lipid Metabolism in Adolescents

Resource links provided by NLM:

Further study details as provided by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD):

Primary Outcome Measures:
  • Fat distribution, insulin sensitivity, glucose production, gluconeogenesis, glycogenolysis [ Time Frame: In response to a 12 wk exercise program. ]

Secondary Outcome Measures:
  • Lipolysis, blood lipids, adiponectin, leptin and CRP [ Time Frame: In response to a 12 wk exercise program ]

Estimated Enrollment: 42
Study Start Date: February 2004
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Post pubertal, sedentary lean and obese Hispanic adolescents
Behavioral: Exercise
12 wk aerobic or/ resistance exercise program

Detailed Description:
Lean and Obese post pubertal adolescents perform an aerobic exercise program 30 minx4/week at a heart rate corresponding to at least 70% of that obtained at VO2 peak. The exercise program is preceded and followed by a 7 d diet delivered by the metabolic research kitchen (identical on both study occasions); metabolic studies (identical on both study occasions) including 24h calorimetry, measurements of glucose and lipid metabolism and insulin sensitivity and secretion using compounds labelled with stable i.e. non radioactive isotopes and gas chromatography-mass spectrometry.Fat mass and lean body mass are measured by DXA and visceral/subcutaneous, hepatic and intramyocellular fat by MRI/MRS. Since we want to specifically determine the effects of exercise, there is no intent of weight loss. The subjects are weighed twice a week to assure weight stability.

Ages Eligible for Study:   13 Years to 17 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Sedentary, post pubertal, Hispanic lean and obese adolescents

Inclusion Criteria:

  • Healthy
  • No medication
  • Sedentary
  • No first degree relative with diabetes,
  • Hispanic
  • BMI >30 or <25 kg/m2.

Exclusion Criteria:

  • Any medication including birth control pills
  • Performing more than >45 min of moderate to light physical activity/week
  • Chronic illness
  Contacts and Locations
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Please refer to this study by its identifier: NCT00998855

Contact: Agneta L Sunehag, M.D., Ph.D. 713 798 6725

United States, Texas
Baylor College of Medicine Recruiting
Houston, Texas, United States, 77030
Contact: Agneta L Sunehag, M.D., Ph.D    713-798-6725   
Principal Investigator: Agneta L Sunehag, M.D., Ph.D         
Sponsors and Collaborators
National Institutes of Health (NIH)
Principal Investigator: Agneta L Sunehag, M.D., Ph.D Baylor College of Medicine
  More Information

Responsible Party: Agneta L Sunehag M.D., Ph.D., Baylor College of Medicine, Houston TX Identifier: NCT00998855     History of Changes
Other Study ID Numbers: sunehagexercise
Study First Received: October 20, 2009
Last Updated: June 6, 2011

Keywords provided by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD):
Exercise in obesity

Additional relevant MeSH terms:
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases processed this record on April 28, 2017