Optimizing Resuscitation After Cardiac Arrest in the Community

This study is ongoing, but not recruiting participants.

Sponsor:

ClinicalTrials.gov Identifier:

NCT00998140

First Posted: October 20, 2009

Last Update Posted: April 28, 2017

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.

Information provided by (Responsible Party):

Dr Sharon Einav, Shaare Zedek Medical Center

Purpose

Resuscitative efforts have been shown to be unsuccessful in most cases of out-of-hospital cardiac arrest (OHCA), and survivors who do recover cardiac function often sustain severe hypoxic brain damage. Time to efficacious care is a primary determinant of disability-free survival. In the Jerusalem district, only 9% of OHCA patients present with ventricular tachycardia/ventricular fibrillation (VT/VF) as the primary rhythm, whereas 77% present with asystole; this seems primarily to be the result of long collapse-to-arrival times. Nevertheless, overly zealous resuscitation is undertaken in a high proportion of arrests with a futile prognosis, leading to excessive costs.

Study hypotheses:

Subpopulations for whom intervention is futile/counter-productive are identifiable
Substantial waste of resources can be avoided
Optimization of emergency medical services (EMS) reorganization without adding resources is an achievable goal

Condition
Cardiopulmonary Arrest Outcome


Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Other
Official Title:	Optimizing Resuscitation After Cardiac Arrest in the Community: Increasing the Probability of Survival While Reducing Costs

Resource links provided by NLM:

MedlinePlus related topics: Cardiac Arrest

Genetic and Rare Diseases Information Center resources: Paroxysmal Ventricular Fibrillation

U.S. FDA Resources

Further study details as provided by Dr Sharon Einav, Shaare Zedek Medical Center:


Estimated Enrollment:	1600
Study Start Date:	March 2009
Estimated Study Completion Date:	March 2020
Estimated Primary Completion Date:	September 2019 (Final data collection date for primary outcome measure)

Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:	18 Years and older (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

All victims of non-traumatic out-of hospital cardiopulmonary arrest (defined as the absence of either spontaneous respiration or palpable pulse or both) within the Jerusalem district.

Criteria

Inclusion Criteria:

All victims of non-traumatic out-of hospital cardiopulmonary arrest (defined as the absence of either spontaneous respiration or palpable pulse or both) within the Jerusalem district.

Exclusion Criteria:

Patients with do-not-resuscitate orders or an advance directive to that effect.

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00998140

Locations


Israel
Shaare Zedek Medical Center
Jerusalem, Israel

Sponsors and Collaborators

Shaare Zedek Medical Center

Investigators


Principal Investigator:	Sharon Einav, MD	Shaare Zedek Medical Center

More Information

Publications:

Pachys G, Kaufman N, Bdolah-Abram T, Kark JD, Einav S. Predictors of long-term survival after out-of-hospital cardiac arrest: the impact of Activities of Daily Living and Cerebral Performance Category scores. Resuscitation. 2014 Aug;85(8):1052-8. doi: 10.1016/j.resuscitation.2014.03.312. Epub 2014 Apr 12.


Responsible Party:	Dr Sharon Einav, Dr., Shaare Zedek Medical Center
ClinicalTrials.gov Identifier:	NCT00998140 History of Changes
Other Study ID Numbers:	NIHPR 08/90/a
First Submitted:	October 18, 2009
First Posted:	October 20, 2009
Last Update Posted:	April 28, 2017
Last Verified:	April 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD:	Yes

Keywords provided by Dr Sharon Einav, Shaare Zedek Medical Center:


resuscitation sudden death cardiopulmonary resuscitation emergency medical services termination of resuscitation ventricular fibrillation out-of-hospital cardiac arrest	asystole medical futility withdrawing treatment transportation of patients health expenditures healthcare costs

Additional relevant MeSH terms:


Heart Arrest Heart Diseases Cardiovascular Diseases

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